Next Article in Journal
Mechanisms of Testicular Disruption from Exposure to Bisphenol A and Phtalates
Next Article in Special Issue
Cerebellar Astrocytes: Much More Than Passive Bystanders In Ataxia Pathophysiology
Previous Article in Journal
Association of rs699947 (−2578 C/A) and rs2010963 (−634 G/C) Single Nucleotide Polymorphisms of the VEGF Gene, VEGF-A and Leptin Serum Level, and Cardiovascular Risk in Patients with Excess Body Mass: A Case–Control Study
Previous Article in Special Issue
GDNF, A Neuron-Derived Factor Upregulated in Glial Cells during Disease
Review

Regulation of Oligodendrocyte Functions: Targeting Lipid Metabolism and Extracellular Matrix for Myelin Repair

Department of Phamacological and Biomolecular Sciences, Università degli Studi di Milano, Via Balzaretti, 9-20133 Milan, Italy
*
Author to whom correspondence should be addressed.
Davide Lecca and Marta Fumagalli are joint senior authors.
J. Clin. Med. 2020, 9(2), 470; https://doi.org/10.3390/jcm9020470
Received: 30 December 2019 / Revised: 30 January 2020 / Accepted: 4 February 2020 / Published: 8 February 2020
(This article belongs to the Special Issue Glial Cells in Central Nervous System (CNS) Pathology and Repair)
Myelin is an essential structure that protects axons, provides metabolic support to neurons and allows fast nerve transmission. Several neurological diseases, such as multiple sclerosis, are characterized by myelin damage, which is responsible of severe functional impairment. Myelin repair requires the timely recruitment of adult oligodendrocyte precursor cells (OPCs) at the lesion sites, their differentiation and maturation into myelinating oligodendrocytes. As a consequence, OPCs undergo profound changes in their morphology, functions, and interactions with other cells and extracellular environment, thus requiring the reorganization of both their lipid metabolism and their membrane composition, which is substantially different compared to other plasma membranes. Despite the growing knowledge in oligodendroglia biology and in the mechanisms involved in OPC-mediated regeneration, the identification of strategies to promote remyelination still remains a challenge. Here, we describe how altered lipid metabolism in oligodendrocytes influences the pathogenesis of demyelination, and we show that several FDA-approved drugs with a previously unknown remyelination potential do act on cholesterol and lipid biosynthetic pathways. Since the interplay between myelin lipids and axons is strictly coordinated by the extracellular matrix (ECM), we also discuss the role of different ECM components, and report the last findings on new ECM-modifiers able to foster endogenous remyelination. View Full-Text
Keywords: myelin; lipid metabolism; extracellular matrix; remyelination myelin; lipid metabolism; extracellular matrix; remyelination
Show Figures

Figure 1

MDPI and ACS Style

Marangon, D.; Boccazzi, M.; Lecca, D.; Fumagalli, M. Regulation of Oligodendrocyte Functions: Targeting Lipid Metabolism and Extracellular Matrix for Myelin Repair. J. Clin. Med. 2020, 9, 470. https://doi.org/10.3390/jcm9020470

AMA Style

Marangon D, Boccazzi M, Lecca D, Fumagalli M. Regulation of Oligodendrocyte Functions: Targeting Lipid Metabolism and Extracellular Matrix for Myelin Repair. Journal of Clinical Medicine. 2020; 9(2):470. https://doi.org/10.3390/jcm9020470

Chicago/Turabian Style

Marangon, Davide, Marta Boccazzi, Davide Lecca, and Marta Fumagalli. 2020. "Regulation of Oligodendrocyte Functions: Targeting Lipid Metabolism and Extracellular Matrix for Myelin Repair" Journal of Clinical Medicine 9, no. 2: 470. https://doi.org/10.3390/jcm9020470

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop