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Article

Association of rs699947 (−2578 C/A) and rs2010963 (−634 G/C) Single Nucleotide Polymorphisms of the VEGF Gene, VEGF-A and Leptin Serum Level, and Cardiovascular Risk in Patients with Excess Body Mass: A Case–Control Study

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Department of Treatment of Obesity, Metabolic Disorders, and Clinical Dietetics, Poznań University of Medical Sciences, Szamarzewskiego St. 82/84, 60-569 Poznań, Poland
2
Department of Biochemistry and Molecular Biology, Poznań University of Medical Sciences, Święcickiego St. 6, 60-781 Poznań, Poland
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(2), 469; https://doi.org/10.3390/jcm9020469
Received: 14 January 2020 / Revised: 4 February 2020 / Accepted: 5 February 2020 / Published: 8 February 2020
(This article belongs to the Section Molecular Diagnostics)
Background: Two single nucleotide polymorphisms (SNPs) of the VEGF gene, rs699947 and rs2010963, are responsible for differentiated gene expression. A mutual dependence between VEGF and leptin serum level has been observed. This study investigated the associations between the rs699947 and rs2010963 SNPs of VEGF gene, VEGF-A, and leptin serum concentrations, and cardiometabolic risk of body mass excess. Methods: In this case–control study, 212 subjects with excess body mass and 145 normal-weight controls gave blood samples and underwent anthropometric and pulse wave analysis. Genotyping of VEGF gene was carried out to analyze the rs699947 (−2578 C/A) and rs2010963 (−634 G/C) SNPs. (ClinicalTrials.gov ID: NCT04077554). Results: This study showed a significant positive correlation between serum levels of VEGF-A and leptin in individuals with excess body mass possessing the CC genotype of the rs699947 variant of the VEGF gene. It has been registered that an increase in VEGF-A serum level correlates with an increase in arterial stiffness in excess body mass patients harboring AA genotype of the rs699947 (−2578 C/A) variant of the VEGF gene. No differences in VEGF-A and leptin serum concentrations were noted between particular genotypes. Conclusions: The CC genotype of the rs699947 variant of the VEGF gene promotes a positive interdependency between leptin and VEGF-A serum levels in subjects with excess body mass. View Full-Text
Keywords: vascular endothelial growth factor; leptin; obesity; VEGF gene polymorphism; cardiovascular risk vascular endothelial growth factor; leptin; obesity; VEGF gene polymorphism; cardiovascular risk
MDPI and ACS Style

Skrypnik, D.; Mostowska, A.; Jagodziński, P.P.; Bogdański, P. Association of rs699947 (−2578 C/A) and rs2010963 (−634 G/C) Single Nucleotide Polymorphisms of the VEGF Gene, VEGF-A and Leptin Serum Level, and Cardiovascular Risk in Patients with Excess Body Mass: A Case–Control Study. J. Clin. Med. 2020, 9, 469. https://doi.org/10.3390/jcm9020469

AMA Style

Skrypnik D, Mostowska A, Jagodziński PP, Bogdański P. Association of rs699947 (−2578 C/A) and rs2010963 (−634 G/C) Single Nucleotide Polymorphisms of the VEGF Gene, VEGF-A and Leptin Serum Level, and Cardiovascular Risk in Patients with Excess Body Mass: A Case–Control Study. Journal of Clinical Medicine. 2020; 9(2):469. https://doi.org/10.3390/jcm9020469

Chicago/Turabian Style

Skrypnik, Damian, Adrianna Mostowska, Paweł P. Jagodziński, and Paweł Bogdański. 2020. "Association of rs699947 (−2578 C/A) and rs2010963 (−634 G/C) Single Nucleotide Polymorphisms of the VEGF Gene, VEGF-A and Leptin Serum Level, and Cardiovascular Risk in Patients with Excess Body Mass: A Case–Control Study" Journal of Clinical Medicine 9, no. 2: 469. https://doi.org/10.3390/jcm9020469

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