Association of rs699947 (−2578 C/A) and rs2010963 (−634 G/C) Single Nucleotide Polymorphisms of the VEGF Gene, VEGF-A and Leptin Serum Level, and Cardiovascular Risk in Patients with Excess Body Mass: A Case–Control Study

Skrypnik, Damian; Mostowska, Adrianna; Jagodziński, Paweł Piotr; Bogdański, Paweł

doi:10.3390/jcm9020469

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Association of rs699947 (−2578 C/A) and rs2010963 (−634 G/C) Single Nucleotide Polymorphisms of the VEGF Gene, VEGF-A and Leptin Serum Level, and Cardiovascular Risk in Patients with Excess Body Mass: A Case–Control Study

Damian Skrypnik

^1,*

Adrianna Mostowska

Paweł Piotr Jagodziński

and

Paweł Bogdański

Department of Treatment of Obesity, Metabolic Disorders, and Clinical Dietetics, Poznań University of Medical Sciences, Szamarzewskiego St. 82/84, 60-569 Poznań, Poland

Department of Biochemistry and Molecular Biology, Poznań University of Medical Sciences, Święcickiego St. 6, 60-781 Poznań, Poland

Author to whom correspondence should be addressed.

J. Clin. Med. 2020, 9(2), 469; https://doi.org/10.3390/jcm9020469

Received: 14 January 2020 / Revised: 4 February 2020 / Accepted: 5 February 2020 / Published: 8 February 2020

(This article belongs to the Section Molecular Diagnostics)

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Abstract

Background: Two single nucleotide polymorphisms (SNPs) of the VEGF gene, rs699947 and rs2010963, are responsible for differentiated gene expression. A mutual dependence between VEGF and leptin serum level has been observed. This study investigated the associations between the rs699947 and rs2010963 SNPs of VEGF gene, VEGF-A, and leptin serum concentrations, and cardiometabolic risk of body mass excess. Methods: In this case–control study, 212 subjects with excess body mass and 145 normal-weight controls gave blood samples and underwent anthropometric and pulse wave analysis. Genotyping of VEGF gene was carried out to analyze the rs699947 (−2578 C/A) and rs2010963 (−634 G/C) SNPs. (ClinicalTrials.gov ID: NCT04077554). Results: This study showed a significant positive correlation between serum levels of VEGF-A and leptin in individuals with excess body mass possessing the CC genotype of the rs699947 variant of the VEGF gene. It has been registered that an increase in VEGF-A serum level correlates with an increase in arterial stiffness in excess body mass patients harboring AA genotype of the rs699947 (−2578 C/A) variant of the VEGF gene. No differences in VEGF-A and leptin serum concentrations were noted between particular genotypes. Conclusions: The CC genotype of the rs699947 variant of the VEGF gene promotes a positive interdependency between leptin and VEGF-A serum levels in subjects with excess body mass. View Full-Text

Keywords: vascular endothelial growth factor; leptin; obesity; VEGF gene polymorphism; cardiovascular risk

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

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Skrypnik, D.; Mostowska, A.; Jagodziński, P.P.; Bogdański, P. Association of rs699947 (−2578 C/A) and rs2010963 (−634 G/C) Single Nucleotide Polymorphisms of the VEGF Gene, VEGF-A and Leptin Serum Level, and Cardiovascular Risk in Patients with Excess Body Mass: A Case–Control Study. J. Clin. Med. 2020, 9, 469. https://doi.org/10.3390/jcm9020469

AMA Style

Skrypnik D, Mostowska A, Jagodziński PP, Bogdański P. Association of rs699947 (−2578 C/A) and rs2010963 (−634 G/C) Single Nucleotide Polymorphisms of the VEGF Gene, VEGF-A and Leptin Serum Level, and Cardiovascular Risk in Patients with Excess Body Mass: A Case–Control Study. Journal of Clinical Medicine. 2020; 9(2):469. https://doi.org/10.3390/jcm9020469

Chicago/Turabian Style

Skrypnik, Damian, Adrianna Mostowska, Paweł P. Jagodziński, and Paweł Bogdański. 2020. "Association of rs699947 (−2578 C/A) and rs2010963 (−634 G/C) Single Nucleotide Polymorphisms of the VEGF Gene, VEGF-A and Leptin Serum Level, and Cardiovascular Risk in Patients with Excess Body Mass: A Case–Control Study" Journal of Clinical Medicine 9, no. 2: 469. https://doi.org/10.3390/jcm9020469

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Association of rs699947 (−2578 C/A) and rs2010963 (−634 G/C) Single Nucleotide Polymorphisms of the VEGF Gene, VEGF-A and Leptin Serum Level, and Cardiovascular Risk in Patients with Excess Body Mass: A Case–Control Study

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