Next Article in Journal
Prognostic Value of Troponin Elevation in COVID-19 Hospitalized Patients
Previous Article in Journal
When Should We Perform Endoscopic Drainage and Necrosectomy for Walled-Off Necrosis?
Article

Intellectual Abilities of Children with Narcolepsy

1
Pediatric Sleep Unit, Department of Pediatric Clinical Epileptology, Sleep Disorders and Functional Neurology, Hôpital Femme Mère Enfant, Hospices Civils de Lyon, 69500 Lyon, France
2
INSERM, U1028, CNRS, UMR5292, Lyon Neuroscience Research Center, 69500 Lyon, France
3
Université de Paris, CRESS, INSERM, INRAE, 75004 Paris, France
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(12), 4075; https://doi.org/10.3390/jcm9124075
Received: 13 November 2020 / Revised: 11 December 2020 / Accepted: 14 December 2020 / Published: 17 December 2020
(This article belongs to the Section Clinical Neurology)
High cognitive functioning could be a protective factor for school difficulties, behavioral and mood impairments in children with narcolepsy. To investigate this factor, we studied the intellectual abilities of 74 children with narcolepsy (43 boys, 11.7 years old at diagnosis, 91% of cataplexies, 64% obese, 100% HLA positive for DR-DQB1*06:02). All children underwent a one-night polysomnography followed by Multiple Sleep Latency Tests, an evaluation of intelligence quotient (IQ), and filled standardized questionnaires. Thirty-eight percent had high potentialities (HP defined by IQ > 130) and 48% had school difficulties. Using non-parametric tests, we found that HP children reported less difficulties at school and tended to have less impulsivity, conduct, and learning disorders than those without HP. They also tended to be less obese and had less desaturation. Using a multivariate regression analysis, we found an association between the REM sleep percentage and the IQ. REM sleep could be involved in the dynamic changes contributing to the equilibrium of intellectual functioning. This study highlights that despite their frequent school difficulties, narcolepsy per se is unlikely to be a cause of intellectual disability in children. Prompt diagnosis and management of comorbidities such as obesity and obstructive sleep apnea (OSA) could improve cognitive and school performances in these children. View Full-Text
Keywords: cognition; children; REM; intelligence quotient; narcolepsy; obesity; obstructive sleep apnea cognition; children; REM; intelligence quotient; narcolepsy; obesity; obstructive sleep apnea
Show Figures

Figure 1

MDPI and ACS Style

Thieux, M.; Zhang, M.; Marcastel, A.; Herbillon, V.; Guignard-Perret, A.; Seugnet, L.; Lin, J.-S.; Guyon, A.; Plancoulaine, S.; Franco, P. Intellectual Abilities of Children with Narcolepsy. J. Clin. Med. 2020, 9, 4075. https://doi.org/10.3390/jcm9124075

AMA Style

Thieux M, Zhang M, Marcastel A, Herbillon V, Guignard-Perret A, Seugnet L, Lin J-S, Guyon A, Plancoulaine S, Franco P. Intellectual Abilities of Children with Narcolepsy. Journal of Clinical Medicine. 2020; 9(12):4075. https://doi.org/10.3390/jcm9124075

Chicago/Turabian Style

Thieux, Marine, Min Zhang, Agathe Marcastel, Vania Herbillon, Anne Guignard-Perret, Laurent Seugnet, Jian-Sheng Lin, Aurore Guyon, Sabine Plancoulaine, and Patricia Franco. 2020. "Intellectual Abilities of Children with Narcolepsy" Journal of Clinical Medicine 9, no. 12: 4075. https://doi.org/10.3390/jcm9124075

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop