Next Article in Journal
The Significance of Apolipoprotein E Measurement in the Screening of Fetal Down Syndrome
Next Article in Special Issue
Canaloplasty in Pigmentary Glaucoma: Long-Term Outcomes and Proposal of a New Hypothesis on Its Intraocular Pressure Lowering Mechanism
Previous Article in Journal
Generic and Respiratory-Specific Quality of Life in Non-Hospitalized Patients with COVID-19
Previous Article in Special Issue
Cannabinoids in Glaucoma Patients: The Never-Ending Story
 
 
Review

Pars Plana Vitrectomy and the Risk of Ocular Hypertension and Glaucoma: Where Are We?

1
IRCCS Policlinico San Martino, 16100 Genoa, Italy
2
IRCCS—Fondazione G.B. Bietti ONLUS, 00100 Rome, Italy
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(12), 3994; https://doi.org/10.3390/jcm9123994
Received: 27 October 2020 / Revised: 30 November 2020 / Accepted: 8 December 2020 / Published: 10 December 2020
(This article belongs to the Special Issue Update on Glaucoma: Pathogenesis and Treatment)
Purpose is to review the pathogenic mechanism for ocular hypertension and glaucoma development after pars plana vitrectomy. Both acute and chronic causes are considered, and special attention is paid to the theories and clinical evidence on the risk of developing Open Angle Glaucoma (OAG) after Pars Plana Vitrectomy (PPV). Most existing scientific literature on the issue agree on the role of ascorbate as an oxygen scavenger within the vitreous chamber. Oxygen tension in the vitreous and anterior chamber is maximum inn proximity of the retinal surface and endothelium, respectively and steeply decreases toward the lens, on both sides, and trabecular meshwork. Vitreous removal and, to a lesser extent, liquefaction, greatly reduces oxygen tension gradient in vitreous chamber while cataract extraction has similar effects on anterior chamber oxygen gradients. Oxygen derivatives originated from the cornea and retina are actively reduced by the vitreous gel and/or the crystalline lens. Vitreous removal and cataract extraction reduce drastically this function. Most reported clinical series confirm this hypothesis although protocol difference and follow-up length greatly impact the reliability of results. View Full-Text
Keywords: ascorbate; pars plana vitrectomy; glaucoma; ocular hypertension; oxidative stress; vitreous metabolism ascorbate; pars plana vitrectomy; glaucoma; ocular hypertension; oxidative stress; vitreous metabolism
MDPI and ACS Style

Rossi, T.; Ripandelli, G. Pars Plana Vitrectomy and the Risk of Ocular Hypertension and Glaucoma: Where Are We? J. Clin. Med. 2020, 9, 3994. https://doi.org/10.3390/jcm9123994

AMA Style

Rossi T, Ripandelli G. Pars Plana Vitrectomy and the Risk of Ocular Hypertension and Glaucoma: Where Are We? Journal of Clinical Medicine. 2020; 9(12):3994. https://doi.org/10.3390/jcm9123994

Chicago/Turabian Style

Rossi, Tommaso, and Guido Ripandelli. 2020. "Pars Plana Vitrectomy and the Risk of Ocular Hypertension and Glaucoma: Where Are We?" Journal of Clinical Medicine 9, no. 12: 3994. https://doi.org/10.3390/jcm9123994

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop