Next Article in Journal
Driver Mutations and Single Copy Number Abnormalities Identify Binet Stage A Patients with Chronic Lymphocytic Leukemia with Aggressive Progression
Next Article in Special Issue
Human Uterus Transplantation from Living and Deceased Donors: The Interim Results of the First 10 Cases of the Czech Trial
Previous Article in Journal
A Retrospective Analysis about Frequency of Monitoring in Italian Chronic Myeloid Leukemia Patients after Discontinuation
Previous Article in Special Issue
Living-Donor Uterus Transplantation: Pre-, Intra-, and Postoperative Parameters Relevant to Surgical Success, Pregnancy, and Obstetrics with Live Births
 
Search for Articles:
Title / Keyword
Author / Affiliation
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
Journals
JCM
Volume 9
Issue 11
10.3390/jcm9113694
jcm-logo
Submit to this Journal Review for this Journal Edit a Special Issue
► Article Menu

Article Menu

share announcement question_answer thumb_up
...
textsms
...
Article

First Successful Delivery after Uterus Transplantation in MHC-Defined Cynomolgus Macaques

by
Iori Kisu
1,*,
Yojiro Kato
2,
Yohei Masugi
3,
Hirohito Ishigaki
4,
Yohei Yamada
5,
Kentaro Matsubara
6,
Hideaki Obara
6,
Katsura Emoto
3,
Yusuke Matoba
1,
Masataka Adachi
1,
Kouji Banno
1,
Yoko Saiki
7,
Takako Sasamura
4,
Iori Itagaki
8,
Ikuo Kawamoto
8,
Chizuru Iwatani
8,
Takahiro Nakagawa
8,
Mitsuru Murase
8,
Hideaki Tsuchiya
8,
Hiroyuki Urano
9,
Masatsugu Ema
8,
Kazumasa Ogasawara
4,
Daisuke Aoki
1,
Kenshi Nakagawa
9 and
Takashi Shiina
10add Show full author list remove Hide full author list
1
Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo 1608582, Japan
2
Department of Surgery, Division of Gastroenterological and General Surgery, School of Medicine, Showa University, Tokyo 1428555, Japan
3
Department of Pathology, Keio University School of Medicine, Tokyo 1608582, Japan
4
Department of Pathology, Shiga University of Medical Science, Shiga 5202192, Japan
5
Department of Pediatric Surgery, Keio University School of Medicine, Tokyo 1608582, Japan
6
Department of Surgery, Keio University School of Medicine, Tokyo 1608582, Japan
7
Department of Anesthesiology, Saiseikai Kanagawaken Hospital, Kanagawa 2210821, Japan
8
Research Center for Animal Life Science, Shiga University of Medical Science, Shiga 5202192, Japan
9
Safety Research Center, Ina Research Inc., Nagano 3994501, Japan
10
Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, Kanagawa 2591193, Japan
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(11), 3694; https://doi.org/10.3390/jcm9113694
Received: 27 September 2020 / Revised: 2 November 2020 / Accepted: 3 November 2020 / Published: 17 November 2020
(This article belongs to the Special Issue Uterus Transplantation)
View Full-Text Download PDF
Browse Figures

Abstract

Delivery following uterus transplantation (UTx)—an approach for treating uterine factor infertility—has not been reported in nonhuman primate models. Here, six female major histocompatibility complex (MHC)-defined cynomolgus macaques that underwent allogeneic UTx were evaluated. Antithymocyte globulin and rituximab were administered to induce immunosuppression and a triple maintenance regimen was used. Menstruation resumed in all animals with long-term survival, except one, which was euthanized due to infusion associated adverse reaction to antithymocyte globulin. Donor-specific antibodies (DSA) were detected in cases 2, 4, and 5, while humoral rejection occurred in cases 4 and 5. Post-transplant lymphoproliferative disorder (PTLD) developed in cases 2 and 3. Pregnancy was attempted in cases 1, 2, and 3 but was achieved only in case 2, which had haploidentical donor and recipient MHCs. Pregnancy was achieved in case 2 after recovery from graft rejection coincident with DSA and PTLD. A cesarean section was performed at full-term. This is the first report of a successful livebirth following allogeneic UTx in nonhuman primates, although the delivery was achieved via UTx between a pair carrying haploidentical MHCs. Experimental data from nonhuman primates may provide important scientific knowledge needed to resolve unsolved clinical issues in UTx. View Full-Text
Keywords: allogeneic uterus transplantation; cynomolgus macaque; donor specific antibody; humoral rejection; post-transplant lymphoproliferative disorder; uterine transplantation; uterine factor infertility; uterus transplantation allogeneic uterus transplantation; cynomolgus macaque; donor specific antibody; humoral rejection; post-transplant lymphoproliferative disorder; uterine transplantation; uterine factor infertility; uterus transplantation
►▼ Show Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Supplementary Material

SciFeed

Share and Cite

MDPI and ACS Style

Kisu, I.; Kato, Y.; Masugi, Y.; Ishigaki, H.; Yamada, Y.; Matsubara, K.; Obara, H.; Emoto, K.; Matoba, Y.; Adachi, M.; Banno, K.; Saiki, Y.; Sasamura, T.; Itagaki, I.; Kawamoto, I.; Iwatani, C.; Nakagawa, T.; Murase, M.; Tsuchiya, H.; Urano, H.; Ema, M.; Ogasawara, K.; Aoki, D.; Nakagawa, K.; Shiina, T. First Successful Delivery after Uterus Transplantation in MHC-Defined Cynomolgus Macaques. J. Clin. Med. 2020, 9, 3694. https://doi.org/10.3390/jcm9113694

AMA Style

Kisu I, Kato Y, Masugi Y, Ishigaki H, Yamada Y, Matsubara K, Obara H, Emoto K, Matoba Y, Adachi M, Banno K, Saiki Y, Sasamura T, Itagaki I, Kawamoto I, Iwatani C, Nakagawa T, Murase M, Tsuchiya H, Urano H, Ema M, Ogasawara K, Aoki D, Nakagawa K, Shiina T. First Successful Delivery after Uterus Transplantation in MHC-Defined Cynomolgus Macaques. Journal of Clinical Medicine. 2020; 9(11):3694. https://doi.org/10.3390/jcm9113694

Chicago/Turabian Style

Kisu, Iori, Yojiro Kato, Yohei Masugi, Hirohito Ishigaki, Yohei Yamada, Kentaro Matsubara, Hideaki Obara, Katsura Emoto, Yusuke Matoba, Masataka Adachi, Kouji Banno, Yoko Saiki, Takako Sasamura, Iori Itagaki, Ikuo Kawamoto, Chizuru Iwatani, Takahiro Nakagawa, Mitsuru Murase, Hideaki Tsuchiya, Hiroyuki Urano, Masatsugu Ema, Kazumasa Ogasawara, Daisuke Aoki, Kenshi Nakagawa, and Takashi Shiina. 2020. "First Successful Delivery after Uterus Transplantation in MHC-Defined Cynomolgus Macaques" Journal of Clinical Medicine 9, no. 11: 3694. https://doi.org/10.3390/jcm9113694

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Article Access Map by Country/Region

1
Back to TopTop