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Open AccessArticle

Cardiovascular Protection of Hydroxychloroquine in Patients with Sjögren’s Syndrome

1
Division of Rheumatology/Immunology/Allergy, Department of Internal Medicine, Taichung Armed-Forces General Hospital, Taichung 411, Taiwan
2
Department of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology, Taichung 406, Taiwan
3
Division of Rheumatology/Immunology/Allergy, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan
4
Department of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan
5
Graduate Institute of Radiological Science, Central Taiwan University of Science and Technology, Taichung 406, Taiwan
6
Department of Rheumatology & Immunology, Chung Shan Medical University Hospital, Taichung 402, Taiwan
7
Institute of Medicine, Chung Shan Medical University, Graduate Institute of Integrated Medicine, China Medical University, Taichung 402, Taiwan
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(11), 3469; https://doi.org/10.3390/jcm9113469
Received: 30 September 2020 / Revised: 20 October 2020 / Accepted: 25 October 2020 / Published: 28 October 2020
Sjögren’s syndrome (SS) is a chronic systemic inflammation disease with clinical presentation of dry eye, dry mouth, and polyarthralgia. Active inflammation is associated with an increased risk of associated arterial stiffness or subclinical atherosclerosis-related cardiovascular events. We used the longitudinal health insurance database of Taiwan, which includes one million participants, to evaluate the relationship between the clinical medication of hydroxychloroquine (HCQ) and the development of coronary artery disease (CAD). In total, 1674 patients with SS receiving HCQ medication were included after exclusion for previous CAD. Altogether, 1142 SS patients were included for evaluation after follow-up for more than one year. After adjusting for age, gender, medications, and chronic comorbidities, a significantly decreased hazard ratio (HR) for developing CAD was found among SS patients with higher medication possession ratio (MPR) of HCQ (HR = 0.49, 95% confidence interval, CI: 0.26–0.94) when compared with low MPR of HCQ. A low HR for CAD was observed in SS patients with a high cumulative dose of at least 100,267 mg of HCQ (HR = 0.25, 95% CI: 0.09–0.66). Long-term HCQ therapy may decrease the HR of CAD in SS patients. The significant cardiovascular protective effect of HCQ therapy was observed in our study. View Full-Text
Keywords: Sjögren’s syndrome; hydroxychloroquine; inflammation; coronary artery disease; cardiovascular event; autoimmune Sjögren’s syndrome; hydroxychloroquine; inflammation; coronary artery disease; cardiovascular event; autoimmune
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MDPI and ACS Style

Yang, D.-H.; Wang, Y.-H.; Pan, L.-F.; Wei, J.C.-C. Cardiovascular Protection of Hydroxychloroquine in Patients with Sjögren’s Syndrome. J. Clin. Med. 2020, 9, 3469. https://doi.org/10.3390/jcm9113469

AMA Style

Yang D-H, Wang Y-H, Pan L-F, Wei JC-C. Cardiovascular Protection of Hydroxychloroquine in Patients with Sjögren’s Syndrome. Journal of Clinical Medicine. 2020; 9(11):3469. https://doi.org/10.3390/jcm9113469

Chicago/Turabian Style

Yang, Deng-Ho; Wang, Yu-Hsun; Pan, Lung-Fa; Wei, James C.-C. 2020. "Cardiovascular Protection of Hydroxychloroquine in Patients with Sjögren’s Syndrome" J. Clin. Med. 9, no. 11: 3469. https://doi.org/10.3390/jcm9113469

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