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Methodological Considerations for Neuroimaging in Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson’s Disease Patients

1
Integrative Model-based Cognitive Neuroscience Research Unit, University of Amsterdam, 1018 WS Amsterdam, The Netherlands
2
Department of Experimental Neurosurgery, Maastricht University Medical Center, 6202 AZ Maastricht, The Netherlands
3
Municipality of Amsterdam, Services & Data, Cluster Social, 1000 AE Amsterdam, The Netherlands
4
Max Planck Institute for Human Cognitive and Brain Sciences, D-04103 Leipzig, Germany
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(10), 3124; https://doi.org/10.3390/jcm9103124
Received: 24 August 2020 / Revised: 17 September 2020 / Accepted: 25 September 2020 / Published: 27 September 2020
(This article belongs to the Special Issue Trends in Clinical Deep Brain Stimulation)
Deep brain stimulation (DBS) of the subthalamic nucleus is a neurosurgical intervention for Parkinson’s disease patients who no longer appropriately respond to drug treatments. A small fraction of patients will fail to respond to DBS, develop psychiatric and cognitive side-effects, or incur surgery-related complications such as infections and hemorrhagic events. In these cases, DBS may require recalibration, reimplantation, or removal. These negative responses to treatment can partly be attributed to suboptimal pre-operative planning procedures via direct targeting through low-field and low-resolution magnetic resonance imaging (MRI). One solution for increasing the success and efficacy of DBS is to optimize preoperative planning procedures via sophisticated neuroimaging techniques such as high-resolution MRI and higher field strengths to improve visualization of DBS targets and vasculature. We discuss targeting approaches, MRI acquisition, parameters, and post-acquisition analyses. Additionally, we highlight a number of approaches including the use of ultra-high field (UHF) MRI to overcome limitations of standard settings. There is a trade-off between spatial resolution, motion artifacts, and acquisition time, which could potentially be dissolved through the use of UHF-MRI. Image registration, correction, and post-processing techniques may require combined expertise of traditional radiologists, clinicians, and fundamental researchers. The optimization of pre-operative planning with MRI can therefore be best achieved through direct collaboration between researchers and clinicians. View Full-Text
Keywords: Parkinson’s disease; magnetic resonance imaging; deep brain stimulation; ultra-high field Parkinson’s disease; magnetic resonance imaging; deep brain stimulation; ultra-high field
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MDPI and ACS Style

Isaacs, B.R.; Keuken, M.C.; Alkemade, A.; Temel, Y.; Bazin, P.-L.; Forstmann, B.U. Methodological Considerations for Neuroimaging in Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson’s Disease Patients. J. Clin. Med. 2020, 9, 3124. https://doi.org/10.3390/jcm9103124

AMA Style

Isaacs BR, Keuken MC, Alkemade A, Temel Y, Bazin P-L, Forstmann BU. Methodological Considerations for Neuroimaging in Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson’s Disease Patients. Journal of Clinical Medicine. 2020; 9(10):3124. https://doi.org/10.3390/jcm9103124

Chicago/Turabian Style

Isaacs, Bethany R., Max C. Keuken, Anneke Alkemade, Yasin Temel, Pierre-Louis Bazin, and Birte U. Forstmann 2020. "Methodological Considerations for Neuroimaging in Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson’s Disease Patients" Journal of Clinical Medicine 9, no. 10: 3124. https://doi.org/10.3390/jcm9103124

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