Next Article in Journal
The Effects of Hyperuricemia on the Prognosis of IgA Nephropathy are More Potent in Females
Next Article in Special Issue
What Are the Most Effective Behavioural Strategies in Changing Postpartum Women’s Physical Activity and Healthy Eating Behaviours? A Systematic Review and Meta-Analysis
Previous Article in Journal
Enhanced Nitric Oxide (NO) and Decreased ADMA Synthesis in Pediatric ADHD and Selective Potentiation of NO Synthesis by Methylphenidate
Previous Article in Special Issue
Health in Preconception, Pregnancy and Postpartum Global Alliance: International Network Preconception Research Priorities for the Prevention of Maternal Obesity and Related Pregnancy and Long-Term Complications
Open AccessArticle

Iodine Status, Thyroid Function, and Birthweight: A Complex Relationship in High-Risk Pregnancies

1
Pediatrics, Obstetrics and Gynecology Unit, Riotinto Hospital, Andalusian Health Service, Av. de la Esquila 5, 21660 Minas de Riotinto Huelva, Spain
2
Germans, Trias I Pujol Research Institute, Carretera de Canyet, s/n, Medicine Department, Autonomous University of Barcelona, 08916 Badalona, Spain
3
Department of Obstetrics & Gynecology, Virgen de las Nieves University Hospital, Andalusian Health Service, Av. de las Fuerzas Armadas 2, 18014 Granada, Spain
4
Thyroid Research Group, Systems Immunity Research Institute, Cardiff University School of Medicine, UHW, C2 Link Corridor, Heath Park, Cardiff CF14 4XN, UK
5
Department of Gastroenterology, Virgen de la Victoria University Hospital, Biomedical Research Institute of Málaga-IBIMA, Biomedical Research Networking Center for Physiopathology of Obesity and Nutrition (CIBEROBN), 29010 Malaga, Spain
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(1), 177; https://doi.org/10.3390/jcm9010177
Received: 8 December 2019 / Revised: 31 December 2019 / Accepted: 6 January 2020 / Published: 8 January 2020
(This article belongs to the Special Issue Health in Preconception Pregnancy and Postpartum)
(1) Background: The consequences of iodine deficiency and/or thyroid dysfunction during pregnancy have been extensively studied, emphasizing on infant neurodevelopment. However, the available information about the relationship between iodine, thyroid hormones, and fetal growth in high-risk pregnancies is limited. We aim to investigate if iodine metabolism and/or thyroid parameters can be affected by adverse antenatal/perinatal conditions. (2) Methods: A cross-sectional study examined differences in iodine status, thyroid function, and birthweight between high-risk (HR group; n = 108)) and low-risk pregnancies (LR group; n = 233) at the time of birth. Urinary iodine concentration (UIC), iodine levels in amniotic fluid, and thyroid parameters [thyroid-stimulating hormone (TSH), free thyroxine (FT4)] were measured in mother–baby pairs. (3) Results: There were significant differences between HR and LR groups, free thyroxine (FT4) concentration in cord blood was significantly higher in the LR group compared with HR pregnancies (17.06 pmol/L vs. 15.30 pmol/L, respectively; p < 0.001), meanwhile iodine concentration in amniotic fluid was significantly lower (13.11 µg/L vs. 19.65 µg/L, respectively; p < 0.001). (4) Conclusions: Our findings support the hypothesis that an adverse intrauterine environment can compromise the availability of FT4 in cord blood as well as the iodine metabolism in the fetus. These differences are more noticeable in preterm and/or small fetuses. View Full-Text
Keywords: iodine; thyroid function; birthweight; amniotic fluid; high-risk pregnancy iodine; thyroid function; birthweight; amniotic fluid; high-risk pregnancy
Show Figures

Figure 1

MDPI and ACS Style

Velasco, I.; Sánchez-Gila, M.; Manzanares, S.; Taylor, P.; García-Fuentes, E. Iodine Status, Thyroid Function, and Birthweight: A Complex Relationship in High-Risk Pregnancies. J. Clin. Med. 2020, 9, 177.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop