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Open AccessArticle

The Serum Cell-Free microRNA Expression Profile in MCTD, SLE, SSc, and RA Patients

1
Department of Molecular Biology, National Institute of Geriatrics, Rheumatology, and Rehabilitation, 02-637 Warsaw, Poland
2
Department of Connective Tissue Diseases, National Institute of Geriatrics, Rheumatology, and Rehabilitation, 02-637 Warsaw, Poland
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(1), 161; https://doi.org/10.3390/jcm9010161 (registering DOI)
Received: 1 December 2019 / Revised: 20 December 2019 / Accepted: 3 January 2020 / Published: 7 January 2020
(This article belongs to the Section Immunology)
Mixed connective tissue disease (MCTD) is a rare disorder characterized by symptoms that overlap two or more Autoimmune Connective Tissue Diseases (ACTDs). The aim of this study was to determine whether miRNAs participating in the TLRs signaling pathway could serve as biomarkers differentiating MCTD or other ACTD entities from a healthy control group and between groups of patients. Although the selected miRNA expression level was not significantly different between MCTD and control, we observed that miR-126 distinguishes MCTD patients from all other ACTD groups. The expression level of miRNAs was significantly higher in the serum of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) patients compared to controls. The miR-145 and -181a levels distinguished RA from other ACDT patients. miR-155 was specific for SLE patients. MiR-132, miR-143, and miR-29a distinguished RA and SLE patients from the systemic sclerosis (SSc) group. Additionally, some clinical parameters were significantly related to the miRNA expression profile in the SLE group. SLE and RA are characterized by a specific serum expression profile of the microRNAs associated with the Toll-like receptors (TLRs) signaling pathway. The analysis showed that their level distinguishes these groups from the control and from other ACTD patients. The present study did not reveal a good biomarker for MCTD patients. View Full-Text
Keywords: microRNA; miRNA serum levels; MCTD; ACTD microRNA; miRNA serum levels; MCTD; ACTD
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Stypinska, B.; Wajda, A.; Walczuk, E.; Olesinska, M.; Lewandowska, A.; Walczyk, M.; Paradowska-Gorycka, A. The Serum Cell-Free microRNA Expression Profile in MCTD, SLE, SSc, and RA Patients. J. Clin. Med. 2020, 9, 161.

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