Next Article in Journal
Subclinical Atherosclerosis Imaging in People Living with HIV
Next Article in Special Issue
Cardiac and Vascular Sympathetic Baroreflex Control during Orthostatic Pre-Syncope
Previous Article in Journal
Is Peri-Implant Probing Causing Over-Diagnosis and Over-Treatment of Dental Implants?
Previous Article in Special Issue
Heart Rate Variability in Sport Performance: Do Time of Day and Chronotype Play A Role?
Open AccessArticle

LRRTM4 and PCSK5 Genetic Polymorphisms as Markers for Cognitive Impairment in A Hypotensive Aging Population: A Genome-Wide Association Study in Taiwan

1
Department of Neurology, Chang Gung Memorial Hospital Linkou Medical Center and College of Medicine, Chang-Gung University, No.5, Fuxing St., Guishan Township, Taoyuan County 333, Taiwan
2
Dementia Center, Chang Gung Memorial Hospital Linkou Medical Center, Taoyuan County 333, Taiwan
3
Center for Neuropsychiatric Research, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County 35053, Taiwan
4
Department of Psychiatry, Taipei Veterans General Hospital, No. 201, Shih-Pai Road, Sec. 2, Taipei 11217, Taiwan
5
Division of Psychiatry, National Yang-Ming University, No.155, Sec.2, Linong Street, Taipei, 112 Taiwan
6
Department of Public Health, Institute of Epidemiology and Preventive Medicine, National Taiwan University, No.17, Xuzhou Rd, Taipei 100, Taiwan
7
Institute of Statistical Science, Academia Sinica, 128 Academia Road, Section 2, Nankang, Taipei 11529, Taiwan
8
Department of Biotechnology, Ming Chuan University, 5 De Ming Rd., Taoyuan City 333, Taiwan
9
Genomic Medicine Research Core Laboratory, Chang Gung Memorial Hospital, No.5, Fuxing St., Guishan Township, Taoyuan County 333, Taiwan
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(8), 1124; https://doi.org/10.3390/jcm8081124
Received: 12 June 2019 / Revised: 16 July 2019 / Accepted: 26 July 2019 / Published: 29 July 2019
(This article belongs to the Special Issue Autonomic Nervous System: From Bench to Bedside)
Hypotension can affect cerebral perfusion and worsen cognitive outcomes. The prevalence of low blood pressure (BP) rises with increasing age. To our knowledge, no study has examined the genetic biomarkers for hypotension-related cognitive impairment (CI) yet. Utilizing the population-based genome-wide study of the Taiwan Biobank containing the data of 2533 healthy aging subjects, we found after adjustments for age, sex, education years, and principal components at a suggestive level of 1 × 10−5 that minor alleles of leucine rich repeat transmembrane neuronal 4 (LRRTM4) (rs13388459, rs1075716, rs62171995, rs17406146, rs2077823, and rs62170897), proprotein convertase subtilisin/kexin type 5 (PCSK5) (rs10521467), and the intergenic variation rs117129097 (the nearby gene: TMEM132C) are risk factors for CI in hypotensive subjects. Except for rs117129097, these single nucleotide polymorphisms (SNPs) were not markers per se for CI or for BP regulation. However, we found a suggestive interaction effect between each of the eight SNPs and hypotension on CI risk. In the hypotensive participants, those carrying minor alleles were associated with a higher incidence of CI in an additive manner than were those carrying major alleles (2 × 10−4 to 9 × 10−7). Intensive BP lowering in elderly patients carrying a minor allele of the eight identified SNPs should raise cautions to prevent a potential treatment-induced neurodegeneration. View Full-Text
Keywords: hypotension; single nucleotide polymorphism; cognitive impairment; dementia hypotension; single nucleotide polymorphism; cognitive impairment; dementia
Show Figures

Figure 1

MDPI and ACS Style

Chen, Y.-C.; Liu, Y.-L.; Tsai, S.-J.; Kuo, P.-H.; Huang, S.-S.; Lee, Y.-S. LRRTM4 and PCSK5 Genetic Polymorphisms as Markers for Cognitive Impairment in A Hypotensive Aging Population: A Genome-Wide Association Study in Taiwan. J. Clin. Med. 2019, 8, 1124.

AMA Style

Chen Y-C, Liu Y-L, Tsai S-J, Kuo P-H, Huang S-S, Lee Y-S. LRRTM4 and PCSK5 Genetic Polymorphisms as Markers for Cognitive Impairment in A Hypotensive Aging Population: A Genome-Wide Association Study in Taiwan. Journal of Clinical Medicine. 2019; 8(8):1124.

Chicago/Turabian Style

Chen, Yi-Chun; Liu, Yu-Li; Tsai, Shih-Jen; Kuo, Po-Hsiu; Huang, Shih-Sin; Lee, Yun-Shien. 2019. "LRRTM4 and PCSK5 Genetic Polymorphisms as Markers for Cognitive Impairment in A Hypotensive Aging Population: A Genome-Wide Association Study in Taiwan" J. Clin. Med. 8, no. 8: 1124.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop