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Open AccessArticle

Clinical Impact of the Fracture Risk Assessment Tool on the Treatment Decision for Osteoporosis in Patients with Knee Osteoarthritis: A Multicenter Comparative Study of the Fracture Risk Assessment Tool and World Health Organization Criteria

1
Division of Rheumatology, Department of Internal Medicine, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung 25440, Korea
2
Department of Rheumatology, Ajou University School of Medicine, Suwon 16449, Korea
3
Division of Rheumatology, Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul 06973, Korea
4
Division of Rheumatology, Department of Internal Medicine, Keimyung University School of Medicine, Dongsan Medical Center, Daegu 42601, Korea
5
Division of Rheumatology, Department of Internal Medicine, Rheumatism Center, Inha University Hospital, Incheon 22332, Korea
*
Authors to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(7), 918; https://doi.org/10.3390/jcm8070918
Received: 6 June 2019 / Revised: 19 June 2019 / Accepted: 22 June 2019 / Published: 26 June 2019
(This article belongs to the Special Issue Pain in Osteoporosis: From Pathophysiology to a Therapeutic Approach)
Background: To compare the frequency of high-risk osteoporotic fracture in patients with knee OA (OA) using the fracture risk assessment tool (FRAX) and the bone mineral density (BMD). Methods: We retrospectively assessed 282 Korean patients with knee OA who visited five medical centers and 1165 healthy controls (HCs) aged ≥50 years without knee OA. After matching for age, sex, and body mass index, 478 subjects (239 patients with knee OA and 239 HCs) were included. Results: Based on the BMD, the frequency of osteoporosis was 40.2% in patients with knee OA and 36.4% in HCs. The predicted mean FRAX major osteoporotic fracture probabilities calculated with or without femur neck BMD differed significantly between the knee OA and HCs (6.9 ± 3.8% versus 6.1 ± 2.8%, p = 0.000 and 8 ± 3.6% versus 6.8 ± 2.3%, p < 0.001, respectively). The mean FRAX hip fracture probabilities calculated with or without femur neck BMD differed significantly in the knee OA and HCs (2.1 ± 2.4% versus 1.7 ± 1.8%, p = 0.006 and 3 ± 2.3% versus 2.4 ± 1.6%, p < 0.001, respectively). Conclusion: Our study suggests that FRAX may have a clinical impact on treatment decisions to reduce osteoporotic facture in patients with knee OA. View Full-Text
Keywords: osteoporosis; fracture; fracture risk assessment tool; knee osteoarthritis osteoporosis; fracture; fracture risk assessment tool; knee osteoarthritis
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MDPI and ACS Style

Kim, B.Y.; Kim, H.-A.; Jung, J.-Y.; Choi, S.T.; Kim, J.-M.; Kim, S.H.; Kwon, S.-R.; Suh, C.-H.; Kim, S.-S. Clinical Impact of the Fracture Risk Assessment Tool on the Treatment Decision for Osteoporosis in Patients with Knee Osteoarthritis: A Multicenter Comparative Study of the Fracture Risk Assessment Tool and World Health Organization Criteria. J. Clin. Med. 2019, 8, 918. https://doi.org/10.3390/jcm8070918

AMA Style

Kim BY, Kim H-A, Jung J-Y, Choi ST, Kim J-M, Kim SH, Kwon S-R, Suh C-H, Kim S-S. Clinical Impact of the Fracture Risk Assessment Tool on the Treatment Decision for Osteoporosis in Patients with Knee Osteoarthritis: A Multicenter Comparative Study of the Fracture Risk Assessment Tool and World Health Organization Criteria. Journal of Clinical Medicine. 2019; 8(7):918. https://doi.org/10.3390/jcm8070918

Chicago/Turabian Style

Kim, Bo Y.; Kim, Hyoun-Ah; Jung, Ju-Yang; Choi, Sang T.; Kim, Ji-Min; Kim, Sang H.; Kwon, Seong-Ryul; Suh, Chang-Hee; Kim, Sung-Soo. 2019. "Clinical Impact of the Fracture Risk Assessment Tool on the Treatment Decision for Osteoporosis in Patients with Knee Osteoarthritis: A Multicenter Comparative Study of the Fracture Risk Assessment Tool and World Health Organization Criteria" J. Clin. Med. 8, no. 7: 918. https://doi.org/10.3390/jcm8070918

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