Next Article in Journal
Treatment Expectations, Convenience, and Satisfaction with Anticoagulant Treatment: Perceptions of Patients in South-East Queensland, Australia
Previous Article in Journal
Bacterial Colonization in Patients with Chronic Lymphocytic Leukemia and Factors Associated with Infections and Colonization
Open AccessArticle

Response-Related Factors of Bone Marrow-Derived Mesenchymal Stem Cells Transplantation in Patients with Alcoholic Cirrhosis

1
Institute for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon 24253, Korea
2
Department of Pathology, Hallym University College of Medicine, Chuncheon 24253, Korea
3
Department of Internal Medicine, Wonju Severance Christian Hospital, Yonsei University, Wonju College of Medicine, Wonju 26426, Korea
*
Author to whom correspondence should be addressed.
The authors contributed equally to this work.
J. Clin. Med. 2019, 8(6), 862; https://doi.org/10.3390/jcm8060862
Received: 9 May 2019 / Revised: 9 June 2019 / Accepted: 14 June 2019 / Published: 17 June 2019
(This article belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Liver cirrhosis leads to hepatic dysfunction and life-threatening conditions. Although the clinical efficacy of autologous bone marrow-derived mesenchymal stem cells (BM-MSC) transplantation in alcoholic cirrhosis (AC) was demonstrated, the relevant mechanism has not been elucidated. We aimed to identify the predictive factors and gene/pathways for responders after autologous BM-MSC transplantation. Fifty-five patients with biopsy-proven AC underwent autologous BM-MSC transplantation. The characteristics of responders who showed improvement in fibrosis score (≥1) after transplantation were compared with those of non-responders. BM-MSCs were analyzed with cDNA microarrays to identify gene/pathways that were differentially expressed in responders. Thirty-three patients (66%) were responders. A high initial Laennec score (p = 0.007, odds ratio 3.73) and performance of BM-MSC transplantation (p = 0.033, odds ratio 5.75) were predictive factors for responders. Three genes (olfactory receptor2L8, microRNA4520-2, and chloride intracellular channel protein3) were upregulated in responders, and CD36 and retinol-binding protein 4 are associated with the biologic processes that are dominant in non-responders. Eleven pathways (inositol phosphate, ATP-binding cassette transporters, protein-kinase signaling, extracellular matrix receptor interaction, endocytosis, phagosome, hematopoietic cell lineage, adipocytokine, peroxisome proliferator-activated receptor, fat digestion/absorption, and insulin resistance) were upregulated in non-responders (p < 0.05). BM-MSC transplantation may be warranted treatment for AC patients with high Laennec scores. Cell-based therapy utilizing response-related genes or pathways can be a treatment candidate. View Full-Text
Keywords: cirrhosis; bone marrow; mesenchymal stem cells; characteristics; liver regeneration cirrhosis; bone marrow; mesenchymal stem cells; characteristics; liver regeneration
Show Figures

Figure 1

MDPI and ACS Style

Gupta, H.; Youn, G.S.; Han, S.H.; Shin, M.J.; Yoon, S.J.; Han, D.H.; Lee, N.Y.; Kim, D.J.; Baik, S.K.; Suk, K.T. Response-Related Factors of Bone Marrow-Derived Mesenchymal Stem Cells Transplantation in Patients with Alcoholic Cirrhosis. J. Clin. Med. 2019, 8, 862. https://doi.org/10.3390/jcm8060862

AMA Style

Gupta H, Youn GS, Han SH, Shin MJ, Yoon SJ, Han DH, Lee NY, Kim DJ, Baik SK, Suk KT. Response-Related Factors of Bone Marrow-Derived Mesenchymal Stem Cells Transplantation in Patients with Alcoholic Cirrhosis. Journal of Clinical Medicine. 2019; 8(6):862. https://doi.org/10.3390/jcm8060862

Chicago/Turabian Style

Gupta, Haripriya; Youn, Gi S.; Han, Sang H.; Shin, Min J.; Yoon, Sang J.; Han, Dae H.; Lee, Na Y.; Kim, Dong J.; Baik, Soon K.; Suk, Ki T. 2019. "Response-Related Factors of Bone Marrow-Derived Mesenchymal Stem Cells Transplantation in Patients with Alcoholic Cirrhosis" J. Clin. Med. 8, no. 6: 862. https://doi.org/10.3390/jcm8060862

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop