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Aerobic Exercise Training Decreases Hepatic Asprosin in Diabetic Rats

National Research Laboratory for Mitochondrial Signaling, Department of Physiology, BK21 Plus Project Team, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan 47392, Korea
Institute of Sports Medicine, Hannam University, Daejeon 34430, Korea
Department of Kinesiology, Inha University, Incheon 22212, Korea
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
J. Clin. Med. 2019, 8(5), 666;
Received: 5 April 2019 / Revised: 29 April 2019 / Accepted: 10 May 2019 / Published: 12 May 2019
(This article belongs to the Special Issue Pathogenetic and Therapeutic Significance of Adipokines in Diabetes)
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Asprosin, a novel hormone released from white adipose tissue, regulates hepatic glucose metabolism and is pathologically elevated in the presence of insulin resistance. It is unknown whether aerobic exercise training affects asprosin levels in type 1 diabetes mellitus (T1DM). The aim of this study was to determine whether (1) aerobic exercise training could decrease asprosin levels in the liver of streptozotocin (STZ)-induced diabetic rats and (2) the reduction in asprosin levels could induce asprosin-dependent downstream pathways. Five-week-old male Sprague–Dawley rats were randomly divided into control, STZ-induced diabetes (STZ), and STZ with aerobic exercise training groups (n = 6/group). T1DM was induced by a single dose of STZ (65 mg/kg intraperitoneally (i.p.)). The exercise group was made to run on a treadmill for 60 min at a speed of 20 m/min, 4 days per week for 8 weeks. Aerobic exercise training reduced the protein levels of asprosin, PKA, and TGF-β but increased those of AMPK, Akt, PGC-1β, and MnSOD. These results suggest that aerobic exercise training affects hepatic asprosin-dependent PKA/TGF-β and AMPK downstream pathways in T1DM. View Full-Text
Keywords: asprosin; PKA; AMPK; TGF-β; aerobic exercise; liver; type 1 diabetes asprosin; PKA; AMPK; TGF-β; aerobic exercise; liver; type 1 diabetes

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Ko, J.R.; Seo, D.Y.; Kim, T.N.; Park, S.H.; Kwak, H.-B.; Ko, K.S.; Rhee, B.D.; Han, J. Aerobic Exercise Training Decreases Hepatic Asprosin in Diabetic Rats. J. Clin. Med. 2019, 8, 666.

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