Elevated CTRP1 Plasma Concentration Is Associated with Sepsis and Pre-Existing Type 2 Diabetes Mellitus in Critically Ill Patients

Yagmur, Eray; Buergerhausen, David; Koek, Ger H.; Weiskirchen, Ralf; Trautwein, Christian; Koch, Alexander; Tacke, Frank

doi:10.3390/jcm8050661

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Elevated CTRP1 Plasma Concentration Is Associated with Sepsis and Pre-Existing Type 2 Diabetes Mellitus in Critically Ill Patients

^1,*

²,

³,

⁴

²,

^2,† and

^2,5,†

Medical Care Center, Dr. Stein and Colleagues, D-41169 Mönchengladbach, Germany

Department of Medicine III, RWTH-University Hospital Aachen, D-52074 Aachen, Germany

Section of Gastroenterology and Hepatology, Department of Internal Medicine, Maastricht University Medical Medical Centre (MUMC), 6202AZ Maastricht, The Netherlands

⁴

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry, RWTH-University Hospital Aachen, D-52074 Aachen, Germany

⁵

Department of Hepatology and Gastroenterology, Charité University Medical Center, D-10117 Berlin, Germany

Author to whom correspondence should be addressed.

^†

These authors contributed equally.

J. Clin. Med. 2019, 8(5), 661; https://doi.org/10.3390/jcm8050661

Received: 1 April 2019 / Revised: 6 May 2019 / Accepted: 7 May 2019 / Published: 11 May 2019

(This article belongs to the Special Issue Pathogenetic and Therapeutic Significance of Adipokines in Diabetes)

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Abstract

The adipokine family of C1q/TNF-like proteins (CTRP) plays a critical role in regulating systemic energy homeostasis and insulin sensitivity. It is involved in pathophysiological processes including inflammation and insulin-resistant obesity. Sepsis is associated with metabolic alterations and dysregulated adipokines, but the role of CTRP1 in critical illness and sepsis is unclear. We investigated CTRP1 plasma concentrations in 145 septic and 73 non-septic critically ill patients at admission to the medical intensive care unit (ICU) in comparison to 66 healthy controls. We also assessed associations of CTRP1 with clinical characteristics, adipokine levels, metabolic and inflammatory parameters. CTRP1 plasma concentration was significantly elevated in critically ill patients compared to healthy subjects. CTRP1 levels were significantly higher in ICU patients with sepsis. CTRP1 correlated strongly with markers of inflammatory response, renal function, liver damage and cholestasis. Furthermore, CTRP1 levels were higher in ICU patients with type 2 diabetes mellitus, and correlated with HbA1c and body mass index. This study demonstrates significantly elevated levels of CTRP1 in critically ill patients, particularly with sepsis, and links circulating CTRP1 to inflammatory and metabolic disturbances. View Full-Text

Keywords: C1q/TNF-related protein 1; CTRP1; ICU; sepsis; inflammation; diabetes; critical illness; glucose metabolism; adipokine; metabolism

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MDPI and ACS Style

Yagmur, E.; Buergerhausen, D.; Koek, G.H.; Weiskirchen, R.; Trautwein, C.; Koch, A.; Tacke, F. Elevated CTRP1 Plasma Concentration Is Associated with Sepsis and Pre-Existing Type 2 Diabetes Mellitus in Critically Ill Patients. J. Clin. Med. 2019, 8, 661. https://doi.org/10.3390/jcm8050661

AMA Style

Yagmur E, Buergerhausen D, Koek GH, Weiskirchen R, Trautwein C, Koch A, Tacke F. Elevated CTRP1 Plasma Concentration Is Associated with Sepsis and Pre-Existing Type 2 Diabetes Mellitus in Critically Ill Patients. Journal of Clinical Medicine. 2019; 8(5):661. https://doi.org/10.3390/jcm8050661

Chicago/Turabian Style

Yagmur, Eray, David Buergerhausen, Ger H. Koek, Ralf Weiskirchen, Christian Trautwein, Alexander Koch, and Frank Tacke. 2019. "Elevated CTRP1 Plasma Concentration Is Associated with Sepsis and Pre-Existing Type 2 Diabetes Mellitus in Critically Ill Patients" Journal of Clinical Medicine 8, no. 5: 661. https://doi.org/10.3390/jcm8050661

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Elevated CTRP1 Plasma Concentration Is Associated with Sepsis and Pre-Existing Type 2 Diabetes Mellitus in Critically Ill Patients

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