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Early Identification of Isolated Sertoli Cell Dysfunction in Prepubertal and Transition Age: Is It Time?

Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy
Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(5), 636;
Received: 8 April 2019 / Revised: 28 April 2019 / Accepted: 7 May 2019 / Published: 9 May 2019
(This article belongs to the Special Issue Disorders of Puberty: The Causes and the Endocrine Medical Treatment)
PDF [647 KB, uploaded 9 May 2019]


The male transitional phase is of fundamental importance for future fertility. This aspect is largely neglected in clinical practice. This opinion aims to shed light on these issues. The children frequently complete the transition phase with a slight reduction of testicular volume. The system of detecting testicular volume is often inadequate. These patients evidently complete puberty in an incomplete way because they do not reach an adequate testicular volume, albeit in the presence of adequate height and regular secondary sexual characteristics. View Full-Text
Keywords: primary prevention; male infertility; male transition primary prevention; male infertility; male transition

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La Vignera, S.; Condorelli, R.A.; Cimino, L.; Cannarella, R.; Giacone, F.; Calogero, A.E. Early Identification of Isolated Sertoli Cell Dysfunction in Prepubertal and Transition Age: Is It Time? J. Clin. Med. 2019, 8, 636.

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