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Urinary Stem Cells as Tools to Study Genetic Disease: Overview of the Literature

1
UOL (Unita` Operativa Logistica) of Medical Genetics, University of Ferrara, 44121 Ferrara, Italy
2
Neuromuscular Unit, Great Ormond Street Hospital, University College London, Bloomsbury, London WC1E 6BT, UK
*
Authors to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(5), 627; https://doi.org/10.3390/jcm8050627
Received: 15 April 2019 / Revised: 3 May 2019 / Accepted: 6 May 2019 / Published: 8 May 2019
(This article belongs to the Special Issue Hereditary Neuromuscular Diseases)
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Abstract

Urine specimens represent a novel and non-invasive approach to isolate patient-specific stem cells by easy and low-cost procedures, replacing the traditional sources (muscle/skin biopsy/adipose tissue) obtained with invasive and time-consuming methods. Urine-derived stem cells (USCs) can be used in a broad field of applications, such as regenerative medicine, cell therapy, diagnostic testing, disease modelling and drug screening. USCs are a good source of cells for generating induced pluripotent stem cells (iPSCs) and importantly, they can also be directly converted into specific cell lines. In this review, we show the features of USCs and their use as a promising in vitro model to study genetic diseases. View Full-Text
Keywords: urinary cells; stem cells; induced pluripotent stem cells; genetic disease; tissue regeneration; differentiation urinary cells; stem cells; induced pluripotent stem cells; genetic disease; tissue regeneration; differentiation
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Falzarano, M.S.; Ferlini, A. Urinary Stem Cells as Tools to Study Genetic Disease: Overview of the Literature. J. Clin. Med. 2019, 8, 627.

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