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UPR: An Upstream Signal to EMT Induction in Cancer

Departamento de Bioquímica, Universidad Autónoma de Madrid, 28029 Madrid, Spain
Instituto de Investigaciones Biomédicas “Alberto Sols” CSIC-UAM, 28029 Madrid, Spain
IdiPAZ, 28029 Madrid, Spain
CIBERONC, 28029 Madrid, Spain
Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(5), 624;
Received: 27 March 2019 / Revised: 30 April 2019 / Accepted: 3 May 2019 / Published: 8 May 2019
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The endoplasmic reticulum (ER) is the organelle where newly synthesized proteins enter the secretory pathway. Different physiological and pathological conditions may perturb the secretory capacity of cells and lead to the accumulation of misfolded and unfolded proteins. To relieve the produced stress, cells evoke an adaptive signalling network, the unfolded protein response (UPR), aimed at recovering protein homeostasis. Tumour cells must confront intrinsic and extrinsic pressures during cancer progression that produce a proteostasis imbalance and ER stress. To overcome this situation, tumour cells activate the UPR as a pro-survival mechanism. UPR activation has been documented in most types of human tumours and accumulating evidence supports a crucial role for UPR in the establishment, progression, metastasis and chemoresistance of tumours as well as its involvement in the acquisition of other hallmarks of cancer. In this review, we will analyse the role of UPR in cancer development highlighting the ability of tumours to exploit UPR signalling to promote epithelial-mesenchymal transition (EMT). View Full-Text
Keywords: epithelial-mesenchymal transition; endoplasmic reticulum stress; metastasis; plasticity; unfolded protein response epithelial-mesenchymal transition; endoplasmic reticulum stress; metastasis; plasticity; unfolded protein response

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Santamaría, P.G.; Mazón, M.J.; Eraso, P.; Portillo, F. UPR: An Upstream Signal to EMT Induction in Cancer. J. Clin. Med. 2019, 8, 624.

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