Next Article in Journal
Selection Criteria for Determination of Optimal Reconstruction Method for Cu-64 Trastuzumab Dosimetry on Siemens Inveon PET Scanner
Previous Article in Journal
Intra-Vitreal Administration of Microvesicles Derived from Human Adipose-Derived Multipotent Stromal Cells Improves Retinal Functionality in Dogs with Retinal Degeneration
Article Menu

Export Article

Open AccessArticle
J. Clin. Med. 2019, 8(4), 511;

Disease-Specific Comorbidity Clusters in COPD and Accelerated Aging

CIRO+, Centre of Expertise for Chronic Organ Failure, 6085 NM Horn, The Netherlands
Department of Respiratory Medicine, MUMC+, Maastricht University Medical Centre, 6229 ER Maastricht, The Netherlands
Department of Respiratory Medicine, AZ Sint-Lucas, 9000 Ghent, Belgium
NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, 6229 ER Maastricht, The Netherlands
Viscovery Software GmbH, 1130 Vienna, Austria
Author to whom correspondence should be addressed.
Received: 17 March 2019 / Revised: 31 March 2019 / Accepted: 11 April 2019 / Published: 14 April 2019
(This article belongs to the Section Pulmonology)
PDF [2528 KB, uploaded 14 April 2019]


Background: Patients with chronic obstructive pulmonary disease (COPD) often suffer from multiple morbidities, which occur in clusters and are sometimes related to accelerated aging. This study aimed to assess the disease specificity of comorbidity clusters in COPD and their association with a biomarker of accelerated aging as a potential mechanistic factor. Methods: Body composition, metabolic, cardiovascular, musculoskeletal, and psychological morbidities were objectively evaluated in 208 COPD patients (age 62 ± 7 years, 58% males, FEV1 50 ± 16% predicted) and 200 non-COPD controls (age 61 ± 7 years, 45% males). Based on their presence and severity, the morbidities were clustered to generate distinct clusters in COPD and controls. Telomere length in circulating leukocytes was compared across the clusters. Results: (co)morbidities were more prevalent in COPD patients compared to controls (3.9 ± 1.7 vs. 2.4 ± 1.5, p < 0.05). A “Psychologic” and “Cachectic” cluster were only present in the COPD population. “Less (co)morbidity”, “Cardiovascular”, and “Metabolic” clusters were also observed in controls, although with less complexity. Telomere length was reduced in COPD patients, but did not differ between the (co)morbidity clusters in both populations. Conclusions: Two COPD-specific comorbidity clusters, a “Cachectic” and “Psychologic” cluster, were identified and warrant further studies regarding their development. Accelerated aging was present across various multimorbidity clusters in COPD. View Full-Text
Keywords: comorbidity; multimorbidity; cluster; COPD; accelerated aging; telomere length comorbidity; multimorbidity; cluster; COPD; accelerated aging; telomere length

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Triest, F.J.J.; Franssen, F.M.E.; Reynaert, N.; Gaffron, S.; Spruit, M.A.; Janssen, D.J.A.; Rutten, E.P.A.; Wouters, E.F.M.; Vanfleteren, L.E.G.W. Disease-Specific Comorbidity Clusters in COPD and Accelerated Aging. J. Clin. Med. 2019, 8, 511.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
J. Clin. Med. EISSN 2077-0383 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top