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Selection Criteria for Determination of Optimal Reconstruction Method for Cu-64 Trastuzumab Dosimetry on Siemens Inveon PET Scanner

Division of RI Application, Korea Institute of Radiological and Medical Sciences (KIRAMS), 75 Nowon-ro, Nowon-gu, Seoul 01812, Korea
Department of Bio-Convergence Engineering, Korea University, Seoul 02856, Korea
Radiologicial and Medico-Oncological Sciences Major, University of Science and Technology (UST), Seoul 01812, Korea
School of Health and Environmental Science, College of Health Science, Korea University, Seoul 02856, Korea
College of Korean Medicine, Kyung Hee University, Seoul 02454, Korea
Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(4), 512;
Received: 28 February 2019 / Revised: 3 April 2019 / Accepted: 10 April 2019 / Published: 14 April 2019
(This article belongs to the Special Issue Advances in Nuclear Medicine Imaging and Therapy)
PDF [5519 KB, uploaded 14 April 2019]


The goal of this study was to suggest criteria for the determination of the optimal image reconstruction algorithm for image-based dosimetry of Cu-64 trastuzumab PET in a mouse model. Image qualities, such as recovery coefficient (RC), spill-over ratio (SOR), and non-uniformity (NU), were measured according to National Electrical Manufacturers Association (NEMA) NU4-2008. Mice bearing a subcutaneous tumor ( 200   mm 3 , HER2 NCI N87) were injected with monoclonal antibodies (trastuzumab) with Cu-64. Preclinical mouse PET images were acquired at 4 time points after injection (2, 15, 40 and 64 h). Phantom and Cu-64 trastuzumab PET images were reconstructed using various reconstruction algorithms (filtered back projection (FBP), 3D reprojection algorithm (FBP-3DRP), 2D ordered subset expectation maximization (OSEM 2D), and OSEM 3D maximum a posteriori (OSEM3D-MAP)) and filters. The absorbed dose for the tumor and the effective dose for organs for Cu-64 trastuzumab PET were calculated using the OLINDA/EXM program with various reconstruction algorithms. Absorbed dose for the tumor ranged from 923 mGy/MBq to 1830 mGy/MBq with application of reconstruction algorithms and filters. When OSEM2D was used, the effective osteogenic dose increased from 0.0031 to 0.0245 with an increase in the iteration number (1 to 10). In the region of kidney, the effective dose increased from 0.1870 to 1.4100 when OSEM2D was used with iteration number 1 to 10. To determine the optimal reconstruction algorithms and filters, a correlation between RC and NU was plotted and selection criteria (0.9 < RC < 1.0 and < 10% of NU) were suggested. According to the selection criteria, OSEM2D (iteration 1) was chosen for the optimal reconstruction algorithm. OSEM2D (iteration 10) provided 154.7% overestimated effective dose and FBP with a Butterworth filter provided 20.9% underestimated effective dose. We suggested OSEM2D (iteration 1) for the calculation of the effective dose of Cu-64 trastuzumab on an Inveon PET scanner. View Full-Text
Keywords: Cu-64; trastuzumab; dosimetry; NEMA NU4-2008 guideline; Inveon PET Cu-64; trastuzumab; dosimetry; NEMA NU4-2008 guideline; Inveon PET

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Lee, S.; Kim, H.; Kang, Y.-R.; Kim, H.; Kim, J.Y.; Lee, Y.-J.; Kim, J.M.; Kim, J.S. Selection Criteria for Determination of Optimal Reconstruction Method for Cu-64 Trastuzumab Dosimetry on Siemens Inveon PET Scanner. J. Clin. Med. 2019, 8, 512.

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