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Fibroblast Growth Factor Family in the Progression of Prostate Cancer

Obesity, Inflammation, and Prostate Cancer

Department of Urology, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan
Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(2), 201;
Received: 19 January 2019 / Revised: 2 February 2019 / Accepted: 4 February 2019 / Published: 6 February 2019
The prevalence of obesity is increasing in the world, and obesity-induced disease, insulin-resistance, cardiovascular disease, and malignancies are becoming a problem. Epidemiological studies have shown that obesity is associated with advanced prostate cancer and that obese men with prostate cancer have a poorer prognosis. Obesity induces systemic inflammation via several mechanisms. High-fat diet-induced prostate cancer progresses via adipose-secretory cytokines or chemokines. Inflammatory cells play important roles in tumor progression. A high-fat diet or obesity changes the local profile of immune cells, such as myeloid-derived suppressor cells and macrophages, in prostate cancer. Tumor-associated neutrophils, B cells, and complements may promote prostate cancer in the background of obesity. Interventions to control systemic and/or local inflammation and changes in lifestyle may also be viable therapies for prostate cancer. View Full-Text
Keywords: obesity; inflammation; prostate cancer; immune cells; cytokine; high-fat diet obesity; inflammation; prostate cancer; immune cells; cytokine; high-fat diet
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MDPI and ACS Style

Fujita, K.; Hayashi, T.; Matsushita, M.; Uemura, M.; Nonomura, N. Obesity, Inflammation, and Prostate Cancer. J. Clin. Med. 2019, 8, 201.

AMA Style

Fujita K, Hayashi T, Matsushita M, Uemura M, Nonomura N. Obesity, Inflammation, and Prostate Cancer. Journal of Clinical Medicine. 2019; 8(2):201.

Chicago/Turabian Style

Fujita, Kazutoshi; Hayashi, Takuji; Matsushita, Makoto; Uemura, Motohide; Nonomura, Norio. 2019. "Obesity, Inflammation, and Prostate Cancer" J. Clin. Med. 8, no. 2: 201.

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