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The Rise of Mitochondria in Peripheral Arterial Disease Physiopathology: Experimental and Clinical Data

1
Unistra, Translational Medicine federation of Strasbourg (FMTS), Faculty of Medicine, Team 3072 «Mitochondria, Oxidative Stress and Muscle Protection», 11 rue Humann, 67000 Strasbourg, France
2
Physiology and Functional Exploration Service, University Hospital of Strasbourg, 1 place de l’Hôpital, 67091 Strasbourg CEDEX, france
3
Internal Medicine, Diabete and Metabolic Diseases Service, University Hospital of Strasbourg, 1 place de l’hôpital, 67091 Strasbourg CEDEX, France
4
Vascular Surgery and Kidney Transplantation Service, University Hospital of Strasbourg, 1 place de l’Hôpital, 67091 Strasbourg CEDEX, France
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(12), 2125; https://doi.org/10.3390/jcm8122125
Received: 10 November 2019 / Revised: 27 November 2019 / Accepted: 29 November 2019 / Published: 2 December 2019
(This article belongs to the Special Issue The Rise of Mitochondria in Medicine)
Peripheral arterial disease (PAD) is a frequent and serious condition, potentially life-threatening and leading to lower-limb amputation. Its pathophysiology is generally related to ischemia-reperfusion cycles, secondary to reduction or interruption of the arterial blood flow followed by reperfusion episodes that are necessary but also—per se—deleterious. Skeletal muscles alterations significantly participate in PAD injuries, and interestingly, muscle mitochondrial dysfunctions have been demonstrated to be key events and to have a prognosis value. Decreased oxidative capacity due to mitochondrial respiratory chain impairment is associated with increased release of reactive oxygen species and reduction of calcium retention capacity leading thus to enhanced apoptosis. Therefore, targeting mitochondria might be a promising therapeutic approach in PAD.
Keywords: peripheral arterial disease; ischemia-reperfusion; mitochondria; oxidative stress; reactive oxygen species; antioxidant; calcium retention capacity; apoptosis peripheral arterial disease; ischemia-reperfusion; mitochondria; oxidative stress; reactive oxygen species; antioxidant; calcium retention capacity; apoptosis
MDPI and ACS Style

Pizzimenti, M.; Riou, M.; Charles, A.-L.; Talha, S.; Meyer, A.; Andres, E.; Chakfé, N.; Lejay, A.; Geny, B. The Rise of Mitochondria in Peripheral Arterial Disease Physiopathology: Experimental and Clinical Data. J. Clin. Med. 2019, 8, 2125.

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