Next Article in Journal
Urinary Oxalate Excretion and Long-Term Outcomes in Kidney Transplant Recipients
Previous Article in Journal
Short and Long Term Clinical and Immunologic Follow up after Bone Marrow Mesenchymal Stromal Cell Therapy in Progressive Multiple Sclerosis—A Phase I Study
Open AccessArticle

Serum Spexin is Correlated with Lipoprotein(a) and Androgens in Female Adolescents

1
Center for Adolescent Medicine and UNESCO Chair on Adolescent Health Care, First Department of Pediatrics, School of Medicine, National and Kapodistrian University of Athens, Aghia Sophia Children’s Hospital, 1 Thivon Street, Goudi, 115 27 Athens, Greece
2
Unit of Clinical and Translational Research in Endocrinology, First Department of Pediatrics, School of Medicine, National and Kapodistrian University of Athens, 1 Thivon Street, Goudi, 115 27 Athens, Greece
3
Department of Bone and Mineral Metabolism, Institute of Child Health, Aghia Sophia Children’s Hospital, 1 Thivon Street, Goudi, 115 27 Athens, Greece
4
Department of Histology, School of Medicine in Katowice, Medical University of Silesia, ul. Medykow 18, 40-752 Katowice, Poland
5
Division of Pediatric-Adolescent Gynecology and Reconstructive Surgery, Second Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, Aretaieio Hospital, 76 Vasilissis Sofias Avenue, 115 28 Athens, Greece
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(12), 2103; https://doi.org/10.3390/jcm8122103
Received: 24 October 2019 / Revised: 23 November 2019 / Accepted: 26 November 2019 / Published: 2 December 2019
(This article belongs to the Section Endocrinology & Metabolism)
The Spexin gene is considered the most dysregulated in obese human fat. Limited data suggest that the novel peptide spexin may potentially impact food intake, weight regulation and body adiposity. The aim of this case-control study was to compare fasting serum spexin concentrations between normal weight (NW) and overweight/obese (OB/OW) adolescent females and explore the relationship between circulating spexin and anthropometric, bone and fat mass, metabolic and hormonal parameters. Eighty post-menarcheal females (mean age ± SD 16.23 ± 2.26 years); 55 NW (mean BMI ± SD 19.72 ± 2.52 kg/m2) and 25 OB/OW (mean BMI ± SD 29.35 ± 3.89 kg/m2) participated in the study. Circulating spexin levels did not differ significantly (p = 0.378) between NW (median (interquartile range), 0.26 (0.17) ng/mL) and OB/OW (median (interquartile range), 0.28 (0.06) ng/mL) adolescents and did not correlate with BMI (rs = −0.090, p = 0.438), % body fat (rs = −0.173, p = 0.409), glucose or insulin resistance indices derived from fasting and oral glucose tolerance states. In the total study sample, spexin concentrations correlated positively with lipoprotein(a) (rs = 0.402, p = 0.046). In the OB/OW adolescents spexin levels correlated positively with testosterone (rs = 0.727, p = 0.011) and free androgen index (rs = 0.755, p = 0.007). In the NW adolescents, spexin concentrations correlated negatively with dehydroepiandrosterone sulphate (rs = −0.445, p = 0.038). Results may suggest potential involvement of spexin in the regulation of lipoprotein(a) and of the reproductive/adrenal axis in post-menarcheal adolescent females. View Full-Text
Keywords: spexin; adolescents; lipoprotein(a); testosterone; free androgen index; DHEAS; androgens; fat mass; overweight; obesity spexin; adolescents; lipoprotein(a); testosterone; free androgen index; DHEAS; androgens; fat mass; overweight; obesity
Show Figures

Figure 1

MDPI and ACS Style

Bacopoulou, F.; Apostolaki, D.; Mantzou, A.; Doulgeraki, A.; Pałasz, A.; Tsimaris, P.; Koniari, E.; Efthymiou, V. Serum Spexin is Correlated with Lipoprotein(a) and Androgens in Female Adolescents. J. Clin. Med. 2019, 8, 2103.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop