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Open AccessArticle

The Sulfate-Reducing Microbial Communities and Meta-Analysis of Their Occurrence during Diseases of Small–Large Intestine Axis

1
Department of Experimental Biology, Faculty of Science, Masaryk University, Kamenice 753/5, 62500 Brno, Czech Republic
2
Department of Plant Origin Foodstuffs Hygiene and Technology, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences, 61242 Brno, Czech Republic
3
Regional Centre of Advanced Technologies and Materials, Faculty of Science, Palacky University in Olomouc, 78371 Olomouc, Czech Republic
4
The Department of Environmental Protection Engineering, Faculty of Technology, Tomas Bata University in Zlín, 76001 Zlín, Czech Republic
5
Department of Biomedical Sciences for Health, University of Milan, 20122 Milan, Italy
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(10), 1656; https://doi.org/10.3390/jcm8101656
Received: 28 August 2019 / Revised: 3 October 2019 / Accepted: 9 October 2019 / Published: 11 October 2019
(This article belongs to the Special Issue Skin-Gut-Breast Microbiota Axes)
Sulfate-reducing bacteria (SRB) are often isolated from animals and people with ulcerative colitis and can be involved in the IBD development in the gut–intestine axis. The background of the research consisted of obtaining mixed cultures of SRB communities from healthy mice and mice with colitis, finding variation in the distribution of their morphology, to determine pH and temperature range tolerance and their possible production of hydrogen sulfide in the small–large intestinal environment. The methods: Microscopic techniques, biochemical, microbiological, and biophysical methods, and statistical processing of the results were used. The results: Variation in the distribution of sulfate-reducing microbial communities were detected. Mixed cultures from mice with ulcerative colitis had 1.39 times higher production of H2S in comparison with samples from healthy mice. The species of Desulfovibrio genus play an important role in diseases of the small–large intestine axis. Meta-analysis was also used for the observation about an SRB occurrence in healthy and not healthy individuals and the same as their metabolic processes. Conclusions: This finding is important for its possible correlation with inflammation of the intestine, where the present of SRB in high concentration plays a major part. It can be a good possible indicator of the occurrence of IBD. View Full-Text
Keywords: bowel disease; colitis; small–large intestine axis; sulfate reduction; hydrogen sulfide bowel disease; colitis; small–large intestine axis; sulfate reduction; hydrogen sulfide
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MDPI and ACS Style

Kushkevych, I.; Leščanová, O.; Dordević, D.; Jančíková, S.; Hošek, J.; Vítězová, M.; Buňková, L.; Drago, L. The Sulfate-Reducing Microbial Communities and Meta-Analysis of Their Occurrence during Diseases of Small–Large Intestine Axis. J. Clin. Med. 2019, 8, 1656.

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