Next Article in Journal
3D Bioprinted Human Cortical Neural Constructs Derived from Induced Pluripotent Stem Cells
Previous Article in Journal
Evaluation of Outcomes and Quality of Care in Children with Sickle Cell Disease Diagnosed by Newborn Screening: A Real-World Nation-Wide Study in France
Open AccessArticle

The White Blood Cell Count to Mean Platelet Volume Ratio for the Prediction of Chronic Limb-Threatening Ischemia in Lower Extremity Artery Disease

1
Division of Vascular Medicine, Department of Internal Medicine, Medical University of Graz, 8036 Graz, Austria
2
Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, 8036 Graz, Austria
3
Department of Radiology, Medical University of Graz, 8036 Graz, Austria
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(10), 1593; https://doi.org/10.3390/jcm8101593
Received: 19 August 2019 / Revised: 19 September 2019 / Accepted: 27 September 2019 / Published: 2 October 2019
(This article belongs to the Section Vascular Medicine)
Background: The white blood cell count to mean platelet volume ratio (WMR) is increasingly gaining importance as a promising prognostic marker in atherosclerotic disease, but data on lower extremity artery disease (LEAD) are not yet available. The principle aim of this study was to assess the association of the WMR with the occurrence of CLTI (chronic limb-threatening ischemia) as the most advanced stage of disease. Methods: This study was performed as a retrospective analysis on 2121 patients with a diagnosis of LEAD. Patients were admitted to the hospital for the reason of LEAD and received conservative or endovascular treatment. Blood sampling, in order to obtain the required values for this analysis, was implemented at admission. Statistical analysis was conducted by univariate regression in a first step and, in case of significance, by multivariate regression additionally. Results: Multivariate regression revealed an increased WMR (p < 0.001, OR (95%CI) 2.258 (1.460–3.492)), but also advanced age (p < 0.001, OR (95%CI) 1.050 (1.040–1.061)), increased CRP (p < 0.001, OR (95%CI) 1.010 (1.007–1.014)), and diabetes (p < 0.001, OR (95%CI) 2.386 (1.933–2.946)) as independent predictors for CLTI. Conclusions: The WMR presents an easily obtainable and cost-effective parameter to identify LEAD patients at high risk for CLTI. View Full-Text
Keywords: atherosclerosis; peripheral arterial disease; lower extremity artery disease; chronic limb-threatening ischemia; platelets; white blood cells atherosclerosis; peripheral arterial disease; lower extremity artery disease; chronic limb-threatening ischemia; platelets; white blood cells
MDPI and ACS Style

Guetl, K.; Raggam, R.B.; Muster, V.; Gressenberger, P.; Vujic, J.; Avian, A.; Hafner, F.; Wehrschuetz, M.; Brodmann, M.; Gary, T. The White Blood Cell Count to Mean Platelet Volume Ratio for the Prediction of Chronic Limb-Threatening Ischemia in Lower Extremity Artery Disease. J. Clin. Med. 2019, 8, 1593.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop