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Open AccessArticle

Validating the Transformation of PROMIS-GH to EQ-5D in Adult Spine Patients

Department of Neurosurgery, Yale School of Medicine, New Haven, CT 06511, USA
Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
Department of Neurosurgery, University of Cincinnati, Cincinnati, OH 45267, USA
Department of Neurosurgery, Geneva University Hospitals, 1205 Geneva, Switzerland
Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY 11549, USA
Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
Author to whom correspondence should be addressed.
Authors contributed equally.
J. Clin. Med. 2019, 8(10), 1506;
Received: 1 August 2019 / Revised: 9 September 2019 / Accepted: 12 September 2019 / Published: 20 September 2019
(This article belongs to the Special Issue Degenerative Cervical Myelopathy and the Aging Spine)
Spinal disorders and associated interventions are costly in the United States, putting them in the limelight of economic analyses. The Patient-Reported Outcomes Measurement Information System Global Health Survey (PROMIS-GHS) requires mapping to other surveys for economic investigation. Previous studies have proposed transformations of PROMIS-GHS to EuroQol 5-Dimension (EQ-5D) health index scores. These models require validation in adult spine patients. In our study, PROMIS-GHS and EQ-5D were randomly administered to 121 adult spine patients. The actual health index scores were calculated from the EQ-5D instrument and estimated scores were calculated from the PROMIS-GHS responses with six models. Goodness-of-fit for each model was determined using the coefficient of determination (R2), mean squared error (MSE), and mean absolute error (MAE). Among the models, the model treating the eight PROMIS-GHS items as categorical variables (CATReg) was the optimal model with the highest R2 (0.59) and lowest MSE (0.02) and MAE (0.11) in our spine sample population. Subgroup analysis showed good predictions of the mean EQ-5D by gender, age groups, education levels, etc. The transformation from PROMIS-GHS to EQ-5D had a high accuracy of mean estimate on a group level, but not at the individual level. View Full-Text
Keywords: EQ-5D; PROMIS; spine; transformation; quality of life; patient outcomes; validation EQ-5D; PROMIS; spine; transformation; quality of life; patient outcomes; validation
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MDPI and ACS Style

Panchagnula, S.; Sun, X.; Montejo, J.D.; Nouri, A.; Kolb, L.; Virojanapa, J.; Camara-Quintana, J.Q.; Sommaruga, S.; Patel, K.; Lakomkin, N.; Abbed, K.; Cheng, J.S. Validating the Transformation of PROMIS-GH to EQ-5D in Adult Spine Patients. J. Clin. Med. 2019, 8, 1506.

AMA Style

Panchagnula S, Sun X, Montejo JD, Nouri A, Kolb L, Virojanapa J, Camara-Quintana JQ, Sommaruga S, Patel K, Lakomkin N, Abbed K, Cheng JS. Validating the Transformation of PROMIS-GH to EQ-5D in Adult Spine Patients. Journal of Clinical Medicine. 2019; 8(10):1506.

Chicago/Turabian Style

Panchagnula, Shreyas; Sun, Xin; Montejo, Julio D.; Nouri, Aria; Kolb, Luis; Virojanapa, Justin; Camara-Quintana, Joaquin Q.; Sommaruga, Samuel; Patel, Kishan; Lakomkin, Nikita; Abbed, Khalid; Cheng, Joseph S. 2019. "Validating the Transformation of PROMIS-GH to EQ-5D in Adult Spine Patients" J. Clin. Med. 8, no. 10: 1506.

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