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Open AccessReview

Proteases and Their Inhibitors in Chronic Obstructive Pulmonary Disease

1
Biological Sciences and Technology Division, CSIR-North East Institute of Science and Technology, Jorhat 785006, Assam, India
2
Centre for Biotechnology and Bioinformatics, Dibrugarh University, Dibrugarh 786004, Assam, India
3
Airway Innate Immunity Research Group, Centre for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University Belfast, Belfast, Northern Ireland BT9 7BL, UK
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2018, 7(9), 244; https://doi.org/10.3390/jcm7090244
Received: 30 July 2018 / Revised: 24 August 2018 / Accepted: 25 August 2018 / Published: 28 August 2018
In the context of respiratory disease, chronic obstructive pulmonary disease (COPD) is the leading cause of mortality worldwide. Despite much development in the area of drug development, currently there are no effective medicines available for the treatment of this disease. An imbalance in the protease: Antiprotease ratio in the COPD lung remains an important aspect of COPD pathophysiology and several studies have shown the efficacy of antiprotease therapy in both in vitro and in vivo COPD models. However more in-depth studies will be required to validate the efficacy of lead drug molecules targeting these proteases. This review discusses the current status of protease-directed drugs used for treating COPD and explores the future prospects of utilizing the potential of antiprotease-based therapeutics as a treatment for this disease. View Full-Text
Keywords: chronic obstructive pulmonary disease; protease; antiprotease chronic obstructive pulmonary disease; protease; antiprotease
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MDPI and ACS Style

Dey, T.; Kalita, J.; Weldon, S.; Taggart, C.C. Proteases and Their Inhibitors in Chronic Obstructive Pulmonary Disease. J. Clin. Med. 2018, 7, 244.

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