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Open AccessArticle

Genetic and Environmental Dispositions for Cardiovascular Variability: A Pilot Study

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Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia
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Department of Anesthesiology and Intensive Care, Clinic for Cardiac Surgery, Clinical Center of Serbia, Koste Todorovica 8, 11000 Belgrade, Serbia
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Institute for Human Genetics, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia
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Department of Physical Medicine and Rehabilitation, University Children’s Hospital, 11000 Belgrade, Serbia
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Clinic for Cardiac Surgery, Clinical Center of Serbia, 11000 Belgrade, Serbia
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Clinic for Cardiology, Clinical Center of Serbia, 11000 Belgrade, Serbia
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2018, 7(9), 232; https://doi.org/10.3390/jcm7090232
Received: 15 July 2018 / Revised: 8 August 2018 / Accepted: 20 August 2018 / Published: 23 August 2018
(This article belongs to the Section Cardiology)
Background: The aim of our study was to evaluate the degree of genetic homozygosity in the group of patients with coronary artery disease (CAD), as well as to evaluate morphogenetic variability in CAD patients regarding the presence of investigated risk factors (RF) compared to a control sample of individuals. Additionally, we aimed to evaluate the distribution of ABO blood type frequencies between tested samples of individuals. Methods: This study analyzed individual phenotype and morphogenetic variability of 17 homozygously-recessive characteristics (HRC), by using HRC test in a sample of 148 individuals in CAD patients group and 156 individuals in the control group. The following RF were analyzed: hypertension, diabetes mellitus, hyperlipidemia, and smoking. Results: The mean value of HRC in CAD patients is significantly higher, while variability decreases compared to the control sample (CAD patients: 4.24 ± 1.59, control sample: 3.75 ± 1.69; VCAD-patients = 37.50%, VC = 45.07%). There is a significant difference in individual variations of 17 HRC between control sample and CAD patients (χ2 = 169.144; p < 0.01), which points out to different variability for tested genes. Mean values of HRC significantly differed in CAD patients in regard to the number of RF present. A blood type (OR = 1.75) is significant predictor for CAD, while O blood type (OR = 0.43) was significantly associated with controls. Conclusion: There is a higher degree of recessive homozygosity in CAD patients versus individuals in the control sample, and the presence of significant variations in the degree of recessive homozygosity as the number of tested RF increases. View Full-Text
Keywords: coronary artery disease; homozygously-recessive characteristics; risk factors; variability; blood groups coronary artery disease; homozygously-recessive characteristics; risk factors; variability; blood groups
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Karan, R.; Cvjeticanin, S.; Kovacevic-Kostic, N.; Nikolic, D.; Velinovic, M.; Milicevic, V.; Obrenovic-Kircanski, B. Genetic and Environmental Dispositions for Cardiovascular Variability: A Pilot Study. J. Clin. Med. 2018, 7, 232.

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