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J. Clin. Med. 2018, 7(10), 340; https://doi.org/10.3390/jcm7100340

The Comparative Associations of Ultrasound and Computed Tomography Estimates of Muscle Quality with Physical Performance and Metabolic Parameters in Older Men

1
Muscle Morphology, Mechanics, and Performance Laboratory, Geriatrics Service, Veterans Affairs Medical Center, Washington, DC 20422, USA
2
Milken Institute School of Public Health, The George Washington University, Washington, DC 20052, USA
3
Research Service, Veterans Affairs Medical Center, Washington, DC 20422, USA
4
Radiology Service, Veterans Affairs Medical Center, Washington, DC 20422, USA
5
Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, The National Institutes of Health, Bethesda, MD 20892, USA
6
Department of Biochemistry & Molecular Medicine, The George Washington University, Washington, DC 20037, USA
7
Department of Medicine, The George Washington University, Washington, DC 20052, USA
8
Nuclear Medicine Section, Veterans Affairs Medical Center, Washington, DC 20422, USA
9
Departments of Medicine and Rehabilitation Medicine, Georgetown University School of Medicine, Washington, DC 20007, USA
*
Author to whom correspondence should be addressed.
Received: 23 September 2018 / Revised: 7 October 2018 / Accepted: 8 October 2018 / Published: 10 October 2018
(This article belongs to the Special Issue Sarcopenia in Older Adults)
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Abstract

Estimates of muscle tissue composition may have greater prognostic value than lean body mass levels regarding health-related outcomes. Ultrasound provides a relatively low cost, safe, and accessible mode of imaging to assess muscle morphology. The purpose of this study was to determine the construct validity of muscle echogenicity as a surrogate measure of muscle quality in a sample of older, predominantly African American (AA) participants. We examined the association of rectus femoris echogenicity with mid-thigh computed tomography (CT) scan estimates of intra- and intermuscular adipose tissue (IMAT), basic metabolic parameters via blood sample analysis, muscle strength, and mobility status. This observational study was conducted at a federal medical center and included 30 community-dwelling men (age, 62.5 ± 9.2; AA, n = 24; Caucasian, n = 6). IMAT estimates were significantly associated with echogenicity (r = 0.73, p < 0.001). Echogenicity and IMAT exhibited similar associations with the two-hour postprandial glucose values and high-density lipoproteins values (p < 0.04), as well as grip and isokinetic (180°/s) knee extension strength adjusted for body size (p < 0.03). The significant relationship between ultrasound and CT muscle composition estimates, and their comparative association with key health-related outcomes, suggests that echogenicity should be further considered as a surrogate measure of muscle quality. View Full-Text
Keywords: aging; muscle tissue composition; echogenicity; sarcopenia; muscle quality; quantitative ultrasound; computed tomography; muscle strength; metabolic status; myosteatosis aging; muscle tissue composition; echogenicity; sarcopenia; muscle quality; quantitative ultrasound; computed tomography; muscle strength; metabolic status; myosteatosis
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Harris-Love, M.O.; Avila, N.A.; Adams, B.; Zhou, J.; Seamon, B.; Ismail, C.; Zaidi, S.H.; Kassner, C.A.; Liu, F.; Blackman, M.R. The Comparative Associations of Ultrasound and Computed Tomography Estimates of Muscle Quality with Physical Performance and Metabolic Parameters in Older Men. J. Clin. Med. 2018, 7, 340.

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