Dehydroepiandrosterone Ameliorates Abnormal Mitochondrial Dynamics and Mitophagy of Cumulus Cells in Poor Ovarian Responders

Li, Chia-Jung; Chen, San-Nung; Lin, Li-Te; Chern, Chyi-Uei; Wang, Peng-Hui; Wen, Zhi-Hong; Tsui, Kuan-Hao

doi:10.3390/jcm7100293

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Dehydroepiandrosterone Ameliorates Abnormal Mitochondrial Dynamics and Mitophagy of Cumulus Cells in Poor Ovarian Responders

^1,2,†

^3,†,

^3,4,5,

³,

^4,6,7

^8,9

and

Kuan-Hao Tsui

^3,4,10,*

Research Assistant Center, Show Chwan Health Memorial Hospital, Changhua 500, Taiwan

Department of Medical Research, Chang Bing Show Chwan Health Memorial Hospital, Changhua 515, Taiwan

Department of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan

⁴

Institute of Clinical Medicine, National Yang-Ming University, Taipei 112, Taiwan

⁵

Department of Biological Science, National Sun Yat-sen University, Kaohsiung 804, Taiwan

⁶

Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei 112, Taiwan

⁷

Department of Medical Research, China Medical University Hospital, Taichung 404, Taiwan

⁸

Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan

⁹

Marine Biomedical Laboratory and Center for Translational Biopharmaceuticals, Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan

¹⁰

Department of Pharmacy and Master Program, College of Pharmacy and Health Care, Tajen University, Pingtung County 813, Taiwan

Author to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

J. Clin. Med. 2018, 7(10), 293; https://doi.org/10.3390/jcm7100293

Received: 21 July 2018 / Revised: 19 September 2018 / Accepted: 19 September 2018 / Published: 20 September 2018

(This article belongs to the Special Issue Autophagy in Infection, Inflammation and Immunity)

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Abstract

Mitochondrial dysfunction is related to reproductive decline in humans, with consequences for in vitro fertilization (IVF). We assessed whether dehydroepiandrosterone (DHEA) could regulate mitochondrial homeostasis and mitophagy of cumulus cells (CCs) in poor ovarian responders (PORs). A total of 66 women who underwent IVF treatment at the Reproductive Medicine Center of Kaohsiung Veterans General Hospital were included in this study. Twenty-eight normal ovarian responders (NOR) and 38 PORs were enrolled. PORs were assigned to receive DHEA supplementation (n = 19) or not (n = 19) before IVF cycles. DHEA prevents mitochondrial dysfunction by decreasing the activation of DNM1L and MFF, and increasing MFN1 expression. Downregulation of PINK1 and PRKN occurred after DHEA treatment, along with increased lysosome formation. DHEA not only promoted mitochondrial mass but also improved mitochondrial homeostasis and dynamics in the CCs of POR. We also observed effects of alterations in mRNAs known to regulate mitochondrial dynamics and mitophagy in the CCs of POR. DHEA may prevent mitochondrial dysfunction through regulating mitochondrial homeostasis and mitophagy. View Full-Text

Keywords: dehydroepiandrosterone; mitochondrial dynamics; mitophagy; cumulus cells; poor ovarian responders

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Li, C.-J.; Chen, S.-N.; Lin, L.-T.; Chern, C.-U.; Wang, P.-H.; Wen, Z.-H.; Tsui, K.-H. Dehydroepiandrosterone Ameliorates Abnormal Mitochondrial Dynamics and Mitophagy of Cumulus Cells in Poor Ovarian Responders. J. Clin. Med. 2018, 7, 293. https://doi.org/10.3390/jcm7100293

AMA Style

Li C-J, Chen S-N, Lin L-T, Chern C-U, Wang P-H, Wen Z-H, Tsui K-H. Dehydroepiandrosterone Ameliorates Abnormal Mitochondrial Dynamics and Mitophagy of Cumulus Cells in Poor Ovarian Responders. Journal of Clinical Medicine. 2018; 7(10):293. https://doi.org/10.3390/jcm7100293

Chicago/Turabian Style

Li, Chia-Jung, San-Nung Chen, Li-Te Lin, Chyi-Uei Chern, Peng-Hui Wang, Zhi-Hong Wen, and Kuan-Hao Tsui. 2018. "Dehydroepiandrosterone Ameliorates Abnormal Mitochondrial Dynamics and Mitophagy of Cumulus Cells in Poor Ovarian Responders" Journal of Clinical Medicine 7, no. 10: 293. https://doi.org/10.3390/jcm7100293

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Dehydroepiandrosterone Ameliorates Abnormal Mitochondrial Dynamics and Mitophagy of Cumulus Cells in Poor Ovarian Responders

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