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Emerging Metabolic Therapies in Pulmonary Arterial Hypertension
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J. Clin. Med. 2017, 6(5), 48;

Nanoparticle-Mediated Drug Delivery System for Pulmonary Arterial Hypertension

Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan
Division of Cardiology, National Hospital Organization Okayama Medical Center, Okayama 701-1192, Japan
Author to whom correspondence should be addressed.
Academic Editor: Jane A. Leopold
Received: 24 January 2017 / Revised: 10 April 2017 / Accepted: 22 April 2017 / Published: 29 April 2017
(This article belongs to the Special Issue Novel Therapeutic Approaches for Pulmonary Arterial Hypertension)
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Nanoparticles have been used as a novel drug delivery system. Drug-incorporated nanoparticles for local delivery might optimize the efficacy and minimize the side effects of drugs. The efficacy and safety of intratracheal administration of prostacyclin analog (beraprost) -incorporated nanoparticles and imatinib (a PDGF-receptor tyrosine kinase inhibitor) -incorporated nanoparticles in Sugen-hypoxia-normoxia or monocrotaline rat models of pulmonary arterial hypertension (PAH) and in human PAH-pulmonary arterial smooth muscle cells have been reported. The use of inhaled drug-incorporated nanoparticles might be a novel approach for the treatment of PAH. View Full-Text
Keywords: pulmonary arterial hypertension; prostacyclin; nanoparticle; drug delivery system pulmonary arterial hypertension; prostacyclin; nanoparticle; drug delivery system

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Nakamura, K.; Matsubara, H.; Akagi, S.; Sarashina, T.; Ejiri, K.; Kawakita, N.; Yoshida, M.; Miyoshi, T.; Watanabe, A.; Nishii, N.; Ito, H. Nanoparticle-Mediated Drug Delivery System for Pulmonary Arterial Hypertension. J. Clin. Med. 2017, 6, 48.

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