Next Article in Journal / Special Issue
Adenosine A2B Receptors: An Optional Target for the Management of Irritable Bowel Syndrome with Diarrhea?
Previous Article in Journal
Is Exaggerated Release of Arginine Vasopressin an Endocrine Disorder? Pathophysiology and Treatment
Previous Article in Special Issue
Pharmacotherapy for Irritable Bowel Syndrome
Open AccessArticle

Gender and Weight Influence Quality of Life in Irritable Bowel Syndrome

Sinclair School of Nursing, University of Missouri-Columbia, Columbia, MO 65211, USA
Digestive Disorders Unit, Biobehavioral Branch, Division of Intramural Research, National Institute of Nursing Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
School of Nursing & Health Studies, Georgetown University, Washington, DC 20007, USA
Author to whom correspondence should be addressed.
Academic Editor: H. Christian Weber
J. Clin. Med. 2017, 6(11), 103;
Received: 19 September 2017 / Revised: 20 October 2017 / Accepted: 27 October 2017 / Published: 1 November 2017
(This article belongs to the Special Issue Irritable Bowel Syndrome)
Irritable bowel syndrome (IBS) is a common gastrointestinal disorder characterized by abdominal pain and bowel dysfunction in the absence of structural abnormality. Diagnosis can be challenging and often leads to extensive medical tests, non-effective therapeutic modalities, and reduced quality of life (QOL). Identifying factors associated with dysfunction have the potential to enhance outcomes. Participants with IBS (n = 41) and healthy volunteers (n = 74) were recruited into this cross-sectional, descriptive, natural history protocol at the National Institute of Health, Clinical Center. Demographic characteristics were self-reported. QOL was assessed with the Irritable Bowel Syndrome Quality of Life (IBS-QOL) questionnaire. Statistical analysis included descriptive statistics, factorial ANOVA, and multiple regression. Individuals with IBS reported lower QOL scores across all QOL-subscales compared to healthy controls. Normal-weight women and overweight men with IBS reported the greatest QOL impairment. Body fat percent had confounding effects on the relationship between IBS and QOL. The disparity between QOL scores in participants with IBS by both gender and weight groups may reflect different social pressures perceived by normal and overweight women and men. These findings enhance the recognition of the disparities in patients with chronic symptoms and thereby lead to personalized assessment and interventions to improve their QOL. View Full-Text
Keywords: irritable bowel syndrome; quality of life; weight; gender; symptoms irritable bowel syndrome; quality of life; weight; gender; symptoms
MDPI and ACS Style

Sherwin, L.B.; Ozoji, O.M.; Boulineaux, C.M.; Joseph, P.V.; Fourie, N.H.; Abey, S.K.; Zhang, X.; Henderson, W.A. Gender and Weight Influence Quality of Life in Irritable Bowel Syndrome. J. Clin. Med. 2017, 6, 103.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop