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Is Exaggerated Release of Arginine Vasopressin an Endocrine Disorder? Pathophysiology and Treatment

Department of Endocrinology and Metabolism, International University of Health and Welfare Hospital, Nasushiobara 329-2763, Tochigi, Japan
J. Clin. Med. 2017, 6(11), 102; https://doi.org/10.3390/jcm6110102
Received: 2 October 2017 / Revised: 27 October 2017 / Accepted: 30 October 2017 / Published: 31 October 2017
Exaggerated release of arginine vasopressin (AVP) is profoundly involved in impaired water excretion and related hyponatremia. Such disorders underlie syndromes of inappropriate secretion of antidiuretic hormone (SIADH) and edematous diseases, such as congestive heart failure and decompensated liver cirrhosis. All the causes are fundamentally from non-endocrine diseases. AVP-induced water retention could produce hyponatremia, and further accelerate poor long-term outcome of edematous diseases. Administration of AVP V2 receptor antagonists verifies how much AVP is involved in the pathogenesis of the impaired water excretion. The present paper demonstrated that exaggerated release of AVP plays a crucial role as an accessory endocrine disorder in pathological states of water retention and dilutional hyponatremia in non-endocrine disorders. View Full-Text
Keywords: impaired water excretion; hyponatremia; aquaporin 2; arterial underfilling; heart failure; SIADH; vasopressin (AVP) V2 receptor antagonist impaired water excretion; hyponatremia; aquaporin 2; arterial underfilling; heart failure; SIADH; vasopressin (AVP) V2 receptor antagonist
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Ishikawa, S.-E. Is Exaggerated Release of Arginine Vasopressin an Endocrine Disorder? Pathophysiology and Treatment. J. Clin. Med. 2017, 6, 102.

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