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J. Clin. Med. 2016, 5(5), 54;

Comparison of Intravenous Anesthetic Agents for the Treatment of Refractory Status Epilepticus

Department of Critical Care Neurology, Columbia University Medical Center, New York, NY 10032, USA
Department of Pharmacy, Weill Cornell Medical Center, New York, NY 10065, USA
Author to whom correspondence should be addressed.
Academic Editors: Gretchen M. Brophy and Paul M. Vespa
Received: 13 April 2016 / Revised: 8 May 2016 / Accepted: 16 May 2016 / Published: 19 May 2016
(This article belongs to the Special Issue Understanding and Treatment of Status Epilepticus)
Full-Text   |   PDF [199 KB, uploaded 19 May 2016]


Status epilepticus that cannot be controlled with first- and second-line agents is called refractory status epilepticus (RSE), a condition that is associated with significant morbidity and mortality. Most experts agree that treatment of RSE necessitates the use of continuous infusion intravenous anesthetic drugs such as midazolam, propofol, pentobarbital, thiopental, and ketamine, each of which has its own unique characteristics. This review compares the various anesthetic agents while providing an approach to their use in adult patients, along with possible associated complications. View Full-Text
Keywords: status epilepticus; refractory status epilepticus; IV anesthetics status epilepticus; refractory status epilepticus; IV anesthetics
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Reznik, M.E.; Berger, K.; Claassen, J. Comparison of Intravenous Anesthetic Agents for the Treatment of Refractory Status Epilepticus. J. Clin. Med. 2016, 5, 54.

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