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Review

Cardioneuroablation in the Management of Vagally Mediated Bradyarrhythmias—A Comprehensive Review of Ongoing Randomized Controlled Trials

by
Przemysław Skoczyński
1,2,†,
Sebastian Stec
3,4,†,
Anna Ratajska
5,6,
Magdalena Zając
5,
Bruno Hrymniak
1,*,
Anna Kustroń
7,
Agnieszka Andrejków
8,
Edyta Stodółkiewicz-Nowarska
9,
Janusz Śledź
4 and
Dariusz Jagielski
1,10
1
Department of Cardiology, Center for Heart Diseases, 4th Military Hospital, 50-981 Wrocław, Poland
2
Department of Emergency Medicine, Wrocław Medical University, 50-368 Wrocław, Poland
3
FESC Department of Cardiac Surgery and Transplantation, National Medical Institute of the Ministry of the Interior and Administration, 02-507 Warsaw, Poland
4
ELMedica, EP-Network, 26-110 Skarzysko-Kamienna, Poland
5
Psychological Therapeutic and Research Center, University Hospital No. 2, 85-168 Bydgoszcz, Poland
6
Department of Humanization, Medicine and Sexology, Institute of Health Sciences, University of Zielona Góra, 65-516 Zielona Góra, Poland
7
BioSphere Research and Trials, 02-507 Warsaw, Poland
8
Clinical Research Support Center, 4th Military Hospital, 50-981 Wrocław, Poland
9
CardioMedicum—Institute for Cardiovascular Research, 30-002 Cracow, Poland
10
Faculty of Medicine, Wrocław University of Science and Technology, 50-370 Wroclaw, Poland
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
J. Clin. Med. 2025, 14(2), 592; https://doi.org/10.3390/jcm14020592
Submission received: 11 December 2024 / Revised: 13 January 2025 / Accepted: 15 January 2025 / Published: 17 January 2025
(This article belongs to the Special Issue Cardiac Electrophysiology: New Insights and Future Directions)
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Abstract

Cardioneuroablation is a rapidly developing procedure for the treatment of vagally mediated bradyarrhythmias. However, the lack of multicenter, randomized trials prevents it from being included in bradyarrhythmia treatment guidelines. So far, only one small, randomized study has been published assessing the effectiveness of this method in the treatment of reflex syncope. This is a brief review of ongoing randomized trials evaluating the effectiveness and safety of cardioneuroablation for the treatment of functional bradyarrhythmias.
Keywords: cardioneuroablation (CNA); vagally mediated bradyarrhythmia cardioneuroablation (CNA); vagally mediated bradyarrhythmia

Share and Cite

MDPI and ACS Style

Skoczyński, P.; Stec, S.; Ratajska, A.; Zając, M.; Hrymniak, B.; Kustroń, A.; Andrejków, A.; Stodółkiewicz-Nowarska, E.; Śledź, J.; Jagielski, D. Cardioneuroablation in the Management of Vagally Mediated Bradyarrhythmias—A Comprehensive Review of Ongoing Randomized Controlled Trials. J. Clin. Med. 2025, 14, 592. https://doi.org/10.3390/jcm14020592

AMA Style

Skoczyński P, Stec S, Ratajska A, Zając M, Hrymniak B, Kustroń A, Andrejków A, Stodółkiewicz-Nowarska E, Śledź J, Jagielski D. Cardioneuroablation in the Management of Vagally Mediated Bradyarrhythmias—A Comprehensive Review of Ongoing Randomized Controlled Trials. Journal of Clinical Medicine. 2025; 14(2):592. https://doi.org/10.3390/jcm14020592

Chicago/Turabian Style

Skoczyński, Przemysław, Sebastian Stec, Anna Ratajska, Magdalena Zając, Bruno Hrymniak, Anna Kustroń, Agnieszka Andrejków, Edyta Stodółkiewicz-Nowarska, Janusz Śledź, and Dariusz Jagielski. 2025. "Cardioneuroablation in the Management of Vagally Mediated Bradyarrhythmias—A Comprehensive Review of Ongoing Randomized Controlled Trials" Journal of Clinical Medicine 14, no. 2: 592. https://doi.org/10.3390/jcm14020592

APA Style

Skoczyński, P., Stec, S., Ratajska, A., Zając, M., Hrymniak, B., Kustroń, A., Andrejków, A., Stodółkiewicz-Nowarska, E., Śledź, J., & Jagielski, D. (2025). Cardioneuroablation in the Management of Vagally Mediated Bradyarrhythmias—A Comprehensive Review of Ongoing Randomized Controlled Trials. Journal of Clinical Medicine, 14(2), 592. https://doi.org/10.3390/jcm14020592

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