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Article

Analysis of Risk Factors for Augmented Vertebral Refracture After Percutaneous Kyphoplasty in Osteoporotic Vertebral Compression Fractures

by
Yonghao Wu
,
Shuaiqi Zhu
,
Yuqiao Li
,
Chenfei Zhang
,
Weiwei Xia
,
Zhenqi Zhu
and
Kaifeng Wang
*
Department of Spinal Surgery, Peking University People’s Hospital, No.11 Xizhimen South Street, Beijing 100044, China
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2025, 14(2), 329; https://doi.org/10.3390/jcm14020329
Submission received: 24 November 2024 / Revised: 24 December 2024 / Accepted: 2 January 2025 / Published: 8 January 2025
(This article belongs to the Special Issue Cutting Edge of Minimally Invasive Spine Surgery)
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Abstract

Objectives: The aim of this study was to investigate the incidence of vertebral refractures following percutaneous kyphoplasty (PKP) and to explore risk factors for augmented vertebral refractures, thereby assisting spinal surgeons in clinical practice. Methods: We analyzed the records of 495 patients with single-segment osteoporotic vertebral compression fractures (OVCFs) who were treated with single-entry PKP at our institution from March 2016 to August 2022. Univariate analysis, binary logistic regression, and ROC curve analysis were performed to determine potential risk factors, independent risk factors, and discrimination ability. Results: A total of 168 patients were included in the study, with a median follow-up duration of 7.00 months. In total, 143 patients did not experience vertebral refracture after surgery, while 25 patients did, including 22 augmented vertebral fractures and 3 adjacent vertebral compression refractures. The correction rate of the Cobb angle (p < 0.001; OR = 1.070) and postoperative anti-osteoporosis treatment (p = 0.002; OR = 0.021) were independently associated with augmented vertebral refracture. The ROC curves showed that these variables demonstrated satisfactory predictive values for augmented vertebral refracture. Conclusions: A high degree of restoration of the Cobb angle was the factor contributing to vertebral refracture after PKP. Conversely, postoperative anti-osteoporosis treatment was observed to be a protective factor against subsequent vertebral refracture.
Keywords: osteoporosis; postoperative complications; vertebral body; vertebroplasty osteoporosis; postoperative complications; vertebral body; vertebroplasty

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MDPI and ACS Style

Wu, Y.; Zhu, S.; Li, Y.; Zhang, C.; Xia, W.; Zhu, Z.; Wang, K. Analysis of Risk Factors for Augmented Vertebral Refracture After Percutaneous Kyphoplasty in Osteoporotic Vertebral Compression Fractures. J. Clin. Med. 2025, 14, 329. https://doi.org/10.3390/jcm14020329

AMA Style

Wu Y, Zhu S, Li Y, Zhang C, Xia W, Zhu Z, Wang K. Analysis of Risk Factors for Augmented Vertebral Refracture After Percutaneous Kyphoplasty in Osteoporotic Vertebral Compression Fractures. Journal of Clinical Medicine. 2025; 14(2):329. https://doi.org/10.3390/jcm14020329

Chicago/Turabian Style

Wu, Yonghao, Shuaiqi Zhu, Yuqiao Li, Chenfei Zhang, Weiwei Xia, Zhenqi Zhu, and Kaifeng Wang. 2025. "Analysis of Risk Factors for Augmented Vertebral Refracture After Percutaneous Kyphoplasty in Osteoporotic Vertebral Compression Fractures" Journal of Clinical Medicine 14, no. 2: 329. https://doi.org/10.3390/jcm14020329

APA Style

Wu, Y., Zhu, S., Li, Y., Zhang, C., Xia, W., Zhu, Z., & Wang, K. (2025). Analysis of Risk Factors for Augmented Vertebral Refracture After Percutaneous Kyphoplasty in Osteoporotic Vertebral Compression Fractures. Journal of Clinical Medicine, 14(2), 329. https://doi.org/10.3390/jcm14020329

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