A TAVI Programme Without an On-Site Cardiac Surgery Department: A Single-Center Retrospective Study
Abstract
1. Introduction
2. Methods
2.1. Study Selection, Data Abstraction, and Validity Assessment and Analysis
2.2. Study Endpoints
2.3. Statistical Analysis
3. Results
4. Discussion
Study Limitations
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Variable | N = 149 |
Age (y) (mean ± SD) | 80.5 ± 6.4 |
Female, no. (%) | 75 (50.3%) |
Body-mass index (mean ± SD) | 28 ± 7.1 |
Time from diagnosis to TAVI (mean ± SD) | 55 days ± 9 |
STS score (mean ± SD) | 4.36 ± 2.96 |
EuroSCORE II score (mean ± SD) | 3.16 ± 2.27 |
NYHA class III/IV, no. (%) | 68 (45.6%) |
Previous myocardial infarction, no. (%) (N = 131) | 15 (11.4%) |
Coronary artery disease, no. (%) | 83 (55.7%) |
Prior PCI, no. (%) | 50 (33.5%) |
Peripheral vascular disease (%) | 26 (17.45%) |
Previous valvular surgery, no. (%) | 9 (6%) |
Hypertension, no. (%) | 125 (84%) |
Previous stroke, no. (%) | 20 (13.4%) |
Diabetes Mellitus, no. (%) | 68 (45.6%) |
Hyperlipidemia, no. (%) | 130 (87.2%) |
Atrial fibrillation, no. (%) | 38 (25.5%) |
COPD, no. (%) | 25 (16.8%) |
CKD (eGFR < 60 mL/min/1.73 m2), no. (%) | 41 (27.5%) |
Anemia (Hg < 10 mg/dL), no. | 76 (51%) |
Permanent pacemaker, no. (%) (N = 134) | 10 (7.4%) |
Echocardiographic data | |
Aortic valve area (cm2) | 0.75 ± 0.15 |
Max aortic valve gradient (mm Hg) (mean ± SD) | 75 ± 23.3 |
Mean aortic gradient (mm Hg) (mean ± SD) | 46.9 ± 15.5 |
Peak aortic valve velocity (m/s) (mean ± SD) | 4.59 ± 0.55 |
LVEF, % (mean ± SD) | 57.8 ± 9.9 |
Moderate to severe mitral regurgitation | 8 (5.4%) |
Moderate to severe tricuspid regurgitation | 1 (0.7%) |
CT analysis | |
Calcium, score (mean ± SD), annular | 2065 ± 610 |
Annular Perimeter (mean ± SD) | 76.85 ± 6.57 |
Variables | N = 149 |
Prosthesis type | no. (%) |
Evolut-PRO | 41 (27.5%) |
Edwards SAPIEN 3 | 43 (28.8%) |
ACURATE neo2 | 57 (38.2%) |
Navitor | 8 (5.4%) |
Valve Platform (N) | Size Distribution (%) |
Evolut-PRO (n = 41) | S (40%), M (50%), L (10%) |
Edwards SAPIEN 3 (n = 43) | 23 mm (30%), 26 mm (45%), 29 mm (25%) |
ACURATE neo2 (n = 57) | 26 mm (20%), 29 mm (55%), 34 mm (25%) |
Navitor (n = 8) | 23 mm (37.5%), 25 mm (37.5%), 27 mm (25.0%) |
Valve in bioprosthetic valve (%) | 7 (4.7%) |
Closure device (valve access only) (%) | |
Prostar/Proglide | 21 (14.1%) |
Prostar/Proglide + Angioseal | 86 (57.7%) |
Manta | 42 (28.2%) |
Intra-procedural complications | |
Conversion to surgery | 0 (0%) |
Emergent surgery | 0 (0%) |
Need for a second valve | 1 (0.67%) |
Coronary obstruction | 0 (0%) |
Cardiac tamponade | 0 (0%) |
Annular rupture | 0 (0%) |
Valve migration/embolization | 1 (0.67%) |
In-hospital outcomes | N = 149 |
In-hospital death | 0 (0%) |
Peri-procedural MI | 0 (0%) |
Stroke | 0 (0%) |
Major vascular complication | 1 (0.67%) |
Major bleeding (Type 2 ≥ BARC 3) | 4 (2.68%) |
Permanent pacemaker implantation | 7(4.7%) |
Acute renal failure | 5 (3.36%) |
Hemodialysis | 0 (0%) |
Time to discharge (days, mean ± SD) | 2.1 ± 1.7 |
Echocardiographic findings—in-hospital post-procedural evaluation | |
Ejection fraction, % (mean ± SD) | 60 ± 8 |
mean aortic valve gradient, mm Hg (mean ± SD) | 11.25 ± 6.2 |
Moderate or severe AR | 0 (0%) |
30-day outcomes | |
Mortality | 1/149 (0.67%) |
Myocardial Infarction | 2/149 (1.34%) |
Stroke | 2/149 (1.34%) |
Cardiovascular hospitalization | 7/149 (4.7%) |
HALT | 1 (0.67%) |
Endocarditis | 1 (0.67%) |
Acute coronary syndrome | 2 (1.34%) |
Heart failure | 3 (2%) |
Non-cardiovascular hospitalization | 14 (9.39%) |
Mortality—1 year | |
Total | 6/149 (4.0%) |
Non-cardiac | 5/149 (3.36%) |
Cardiac | 1/149 (0.67%) |
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Barashi, R.; Gabarin, M.; Arow, Z.; Hilu, R.; Losin, I.; Novikov, I.; Abd El Hai, K.; Arnson, Y.; Neuman, Y.; Pesis, K.; et al. A TAVI Programme Without an On-Site Cardiac Surgery Department: A Single-Center Retrospective Study. J. Clin. Med. 2025, 14, 5449. https://doi.org/10.3390/jcm14155449
Barashi R, Gabarin M, Arow Z, Hilu R, Losin I, Novikov I, Abd El Hai K, Arnson Y, Neuman Y, Pesis K, et al. A TAVI Programme Without an On-Site Cardiac Surgery Department: A Single-Center Retrospective Study. Journal of Clinical Medicine. 2025; 14(15):5449. https://doi.org/10.3390/jcm14155449
Chicago/Turabian StyleBarashi, Rami, Mustafa Gabarin, Ziad Arow, Ranin Hilu, Ilya Losin, Ivan Novikov, Karam Abd El Hai, Yoav Arnson, Yoram Neuman, Koby Pesis, and et al. 2025. "A TAVI Programme Without an On-Site Cardiac Surgery Department: A Single-Center Retrospective Study" Journal of Clinical Medicine 14, no. 15: 5449. https://doi.org/10.3390/jcm14155449
APA StyleBarashi, R., Gabarin, M., Arow, Z., Hilu, R., Losin, I., Novikov, I., Abd El Hai, K., Arnson, Y., Neuman, Y., Pesis, K., Jebara, Z., Pereg, D., Koifman, E., Assali, A., & Vaknin-Assa, H. (2025). A TAVI Programme Without an On-Site Cardiac Surgery Department: A Single-Center Retrospective Study. Journal of Clinical Medicine, 14(15), 5449. https://doi.org/10.3390/jcm14155449