Next Article in Journal
The Impact of LDL Cholesterol, HDL Cholesterol, Triglycerides, and Vitamin D on Short-Term Implant Survival Rate: A Prospective Observational Study
Previous Article in Journal
Apigenin Attenuates Hepatic Ischemia–Reperfusion-Induced Lung Injury via Downregulation of MMP-3 and MCP-1: An Experimental Study in Rats
Previous Article in Special Issue
Impact of GLP-1 Receptor Agonists in Gastrointestinal Endoscopy: An Updated Review
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
JCM
Volume 14
Issue 10
10.3390/jcm14103532
jcm-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Review

Endoscopic Management of Ampullary Adenomas: A Comprehensive Review

by
Minh Thu T. Nguyen
1,
Ruchir Paladiya
2,
Dushyant Singh Dahiya
3,* and
Murali Dharan
1
1
Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
2
Department of Internal Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
3
Division of Gastroenterology, Hepatology and Motility, The University of Kansas School of Medicine, Kansas City, KS 66160, USA
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2025, 14(10), 3532; https://doi.org/10.3390/jcm14103532 (registering DOI)
Submission received: 29 March 2025 / Revised: 10 May 2025 / Accepted: 16 May 2025 / Published: 18 May 2025
(This article belongs to the Special Issue Clinical Advances in Endoscopic Ultrasound-Guided Diagnosis and Treatment)
Versions Notes

Abstract

Ampullary adenomas are rare outgrowths at the ampulla of Vater that may progress into cancer via the adenoma-to-carcinoma sequence, particularly in individuals with hereditary polyposis syndrome. Many are diagnosed incidentally or once the lesion becomes large enough to cause obstruction. Traditionally managed surgically with high morbidity and mortality, advances in imaging and therapy have made endoscopic ampullectomy the first-line treatment for noninvasive lesions. Despite its high success rate and favorable safety profile, complications such as pancreatitis, ductal stenosis, bleeding, recurrence, and perforation can occur. Recommendations for optimal endoscopic techniques and surveillance intervals are largely based on expert opinion in interventional endoscopy and findings from small-scale studies. This review provides an updated framework for the diagnosis and management of ampullary adenomas.
Keywords: ampullary adenoma; ampullary adenocarcinoma; endoscopic ampullectomy; endoscopic retrograde cholangiopancreatography; endoscopic ultrasound ampullary adenoma; ampullary adenocarcinoma; endoscopic ampullectomy; endoscopic retrograde cholangiopancreatography; endoscopic ultrasound

Share and Cite

MDPI and ACS Style

Nguyen, M.T.T.; Paladiya, R.; Dahiya, D.S.; Dharan, M. Endoscopic Management of Ampullary Adenomas: A Comprehensive Review. J. Clin. Med. 2025, 14, 3532. https://doi.org/10.3390/jcm14103532

AMA Style

Nguyen MTT, Paladiya R, Dahiya DS, Dharan M. Endoscopic Management of Ampullary Adenomas: A Comprehensive Review. Journal of Clinical Medicine. 2025; 14(10):3532. https://doi.org/10.3390/jcm14103532

Chicago/Turabian Style

Nguyen, Minh Thu T., Ruchir Paladiya, Dushyant Singh Dahiya, and Murali Dharan. 2025. "Endoscopic Management of Ampullary Adenomas: A Comprehensive Review" Journal of Clinical Medicine 14, no. 10: 3532. https://doi.org/10.3390/jcm14103532

APA Style

Nguyen, M. T. T., Paladiya, R., Dahiya, D. S., & Dharan, M. (2025). Endoscopic Management of Ampullary Adenomas: A Comprehensive Review. Journal of Clinical Medicine, 14(10), 3532. https://doi.org/10.3390/jcm14103532

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Article metric data becomes available approximately 24 hours after publication online.
Back to TopTop