Next Article in Journal
Targeting KDM1A in Neuroblastoma with NCL-1 Induces a Less Aggressive Phenotype and Suppresses Angiogenesis
Previous Article in Journal
A 2024 Update on Growth Hormone Deficiency Syndrome in Adults: From Guidelines to Real Life
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
JCM
Volume 13
Issue 20
10.3390/jcm13206080
jcm-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Multi-Ancestry Causal Association between Rheumatoid Arthritis and Interstitial Lung Disease: A Bidirectional Two-Sample Mendelian Randomization Study

by
Bo-Guen Kim
1,†,
Sanghyuk Yoon
2,†,
Sun Yeop Lee
2,
Eun Gyo Kim
2,
Jung Oh Kim
2,
Jong Seung Kim
3,4,*,‡ and
Hyun Lee
5,*,‡
1
Division of Pulmonary Medicine, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, Republic of Korea
2
Basgenbio Inc., Seoul 04167, Republic of Korea
3
Department of Medical Informatics, Jeonbuk National University, Jeonju 54907, Republic of Korea
4
Department of Otorhinolaryngology, Jeonbuk National University, Jeonju 54907, Republic of Korea
5
Division of Pulmonary Medicine and Allergy, Department of Internal Medicine, Hanyang University College of Medicine, 222-1, Wangsimni-ro, Seongdong-gu, Seoul 04763, Republic of Korea
*
Authors to whom correspondence should be addressed.
†
Contributed equally to this work as joint co-first authors.
‡
Contributed equally to this work as joint co-corresponding authors.
J. Clin. Med. 2024, 13(20), 6080; https://doi.org/10.3390/jcm13206080
Submission received: 13 September 2024 / Revised: 6 October 2024 / Accepted: 9 October 2024 / Published: 12 October 2024
(This article belongs to the Section Respiratory Medicine)
Browse Figures
Versions Notes

Abstract

Abstract: Background: Rheumatoid arthritis (RA) is associated with diverse extra-articular manifestations, including interstitial lung disease (ILD). No previous studies have examined the bidirectional relationship between RA and ILD using the Mendelian randomization (MR) analyses. Therefore, we aimed to investigate this subject using a two-sample bidirectional MR method. Methods: We performed bidirectional two-sample MR using summary statistics from genome-wide association studies (GWASs). The data are publicly available, de-identified, and from European (EUR) and East Asian (EAS) ancestries. Results: A total of 474,450 EUR participants and 351,653 EAS participants were included for either forward or reverse MR analysis. In our primary analysis, we found significant evidence of an increased risk of ILD associated with RA among individuals of EUR ancestry (ORMR-cML = 1.08; 95% confidence interval [CI] = 1.03–1.14; p = 0.003) and EAS ancestry (ORMR-cML = 1.37; 95% CI = 1.23–1.54; p < 0.001). Additionally, the reverse MR showed significant evidence of an increased risk of RA associated with ILD among those of EUR ancestry (ORMR-cML = 1.12; 95% CI = 1.05–1.19; p < 0.001). However, only one instrumental variable was selected in the EAS ILD GWAS, and there was no increased risk of RA associated with ILD in those of EAS ancestry (ORMR-cML = 1.02; 95% CI = 0.91–1.14; p = 0.740). Conclusions: Our findings indicate that RA and ILD have a bidirectional causal inference when using the MR analysis of GWAS datasets. The findings are only relevant for genetic predisposition; thus, further research is needed to determine the impact of non-genetic predispositions.
Keywords: rheumatoid arthritis; interstitial lung disease; Mendelian randomization; causal effect; bidirectional rheumatoid arthritis; interstitial lung disease; Mendelian randomization; causal effect; bidirectional

Share and Cite

MDPI and ACS Style

Kim, B.-G.; Yoon, S.; Lee, S.Y.; Kim, E.G.; Kim, J.O.; Kim, J.S.; Lee, H. Multi-Ancestry Causal Association between Rheumatoid Arthritis and Interstitial Lung Disease: A Bidirectional Two-Sample Mendelian Randomization Study. J. Clin. Med. 2024, 13, 6080. https://doi.org/10.3390/jcm13206080

AMA Style

Kim B-G, Yoon S, Lee SY, Kim EG, Kim JO, Kim JS, Lee H. Multi-Ancestry Causal Association between Rheumatoid Arthritis and Interstitial Lung Disease: A Bidirectional Two-Sample Mendelian Randomization Study. Journal of Clinical Medicine. 2024; 13(20):6080. https://doi.org/10.3390/jcm13206080

Chicago/Turabian Style

Kim, Bo-Guen, Sanghyuk Yoon, Sun Yeop Lee, Eun Gyo Kim, Jung Oh Kim, Jong Seung Kim, and Hyun Lee. 2024. "Multi-Ancestry Causal Association between Rheumatoid Arthritis and Interstitial Lung Disease: A Bidirectional Two-Sample Mendelian Randomization Study" Journal of Clinical Medicine 13, no. 20: 6080. https://doi.org/10.3390/jcm13206080

APA Style

Kim, B.-G., Yoon, S., Lee, S. Y., Kim, E. G., Kim, J. O., Kim, J. S., & Lee, H. (2024). Multi-Ancestry Causal Association between Rheumatoid Arthritis and Interstitial Lung Disease: A Bidirectional Two-Sample Mendelian Randomization Study. Journal of Clinical Medicine, 13(20), 6080. https://doi.org/10.3390/jcm13206080

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop