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Article

Intrauterine Infusion and Hysteroscopic Injection of Autologous Platelet-Rich Plasma for Patients with a Persistent Thin Endometrium: A Prospective Case–Control Study

by
Tzu-Ning Yu
1,2,†,
Tsung-Hsien Lee
1,2,3,†,
Maw-Sheng Lee
1,2,3,
Yi-Chun Chen
2,
Chung-I Chen
2,
En-Hui Cheng
2,
Pin-Yao Lin
2,
Chun-Chia Huang
2 and
Chun-I Lee
1,2,3,*
1
Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
2
Division of Infertility, Lee Women’s Hospital, Taichung 406, Taiwan
3
Department of Obstetrics and Gynecology, Chung Shan Medical University Hospital, Taichung 402, Taiwan
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
J. Clin. Med. 2024, 13(10), 2838; https://doi.org/10.3390/jcm13102838
Submission received: 27 March 2024 / Revised: 24 April 2024 / Accepted: 8 May 2024 / Published: 11 May 2024
(This article belongs to the Special Issue Assisted Reproductive Technology: Clinical Advances and Challenges)
Versions Notes

Abstract

Objectives: To evaluate the effect of intrauterine infusion and hysteroscopic injection of autologous platelet-rich plasma (PRP) in patients with a persistent thin endometrium (EM) undergoing euploid frozen embryo transfer (EFET) cycles. Methods: This prospective case–control study enrolled 116 infertile women with thin EM (<7 mm) who underwent hormone replacement therapy (HRT) for EFET. These women had experienced at least one previous unsuccessful EFET cycle, which either resulted in the cancellation of the cycle or failure of pregnancy. A total of 55 women received an intrauterine infusion of PRP before FET, 38 received a hysteroscopic injection of PRP, and 23 received standard HRT treatment without PRP (control group). Only euploid embryos were transferred in these cycles. The primary outcomes were the implantation rate (IR) and clinical pregnancy rate (CPR) after EFET. Results: After receiving intrauterine infusion and hysteroscopic injection of PRP, 78.2% and 55.3% of patients, respectively, showed an EM thickness exceeding 7 mm, followed by embryo transfer. The hysteroscopic injection group demonstrated significantly higher IR (52%), a higher trend of CPR (52%), and a higher live birth rate (38%) than the control group (18%, 22%, and 4%). Conclusions: Intrauterine infusion and hysteroscopic injection of autologous PRP may be effective methods to increase EM thickness in HRT cycles. According to our results, both methods could increase EM thickness, while hysteroscopic injection appeared to provide more significant assistance in increasing IR, CPR, and live birth rate after EFET in patients with persistent thin EM.
Keywords: autologous platelet-rich plasma; intrauterine infusion; hysteroscopic injection; thin endometrium; frozen-thaw embryo transfer autologous platelet-rich plasma; intrauterine infusion; hysteroscopic injection; thin endometrium; frozen-thaw embryo transfer

Share and Cite

MDPI and ACS Style

Yu, T.-N.; Lee, T.-H.; Lee, M.-S.; Chen, Y.-C.; Chen, C.-I.; Cheng, E.-H.; Lin, P.-Y.; Huang, C.-C.; Lee, C.-I. Intrauterine Infusion and Hysteroscopic Injection of Autologous Platelet-Rich Plasma for Patients with a Persistent Thin Endometrium: A Prospective Case–Control Study. J. Clin. Med. 2024, 13, 2838. https://doi.org/10.3390/jcm13102838

AMA Style

Yu T-N, Lee T-H, Lee M-S, Chen Y-C, Chen C-I, Cheng E-H, Lin P-Y, Huang C-C, Lee C-I. Intrauterine Infusion and Hysteroscopic Injection of Autologous Platelet-Rich Plasma for Patients with a Persistent Thin Endometrium: A Prospective Case–Control Study. Journal of Clinical Medicine. 2024; 13(10):2838. https://doi.org/10.3390/jcm13102838

Chicago/Turabian Style

Yu, Tzu-Ning, Tsung-Hsien Lee, Maw-Sheng Lee, Yi-Chun Chen, Chung-I Chen, En-Hui Cheng, Pin-Yao Lin, Chun-Chia Huang, and Chun-I Lee. 2024. "Intrauterine Infusion and Hysteroscopic Injection of Autologous Platelet-Rich Plasma for Patients with a Persistent Thin Endometrium: A Prospective Case–Control Study" Journal of Clinical Medicine 13, no. 10: 2838. https://doi.org/10.3390/jcm13102838

APA Style

Yu, T.-N., Lee, T.-H., Lee, M.-S., Chen, Y.-C., Chen, C.-I., Cheng, E.-H., Lin, P.-Y., Huang, C.-C., & Lee, C.-I. (2024). Intrauterine Infusion and Hysteroscopic Injection of Autologous Platelet-Rich Plasma for Patients with a Persistent Thin Endometrium: A Prospective Case–Control Study. Journal of Clinical Medicine, 13(10), 2838. https://doi.org/10.3390/jcm13102838

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