MTHFR Gene C677T Polymorphism (rs1801133) and Susceptibility to Colorectal Polyps in an Azerbaijani Population
Abstract
:1. Introduction
2. Materials and Methods
2.1. Subjects
2.2. DNA Extraction Genotyping
2.3. Ethical Consideration
2.4. Statistical Analysis
3. Results
3.1. Demographic Characteristics
3.2. Characteristics of Colorectal Polyps
3.3. Genotype and Allele Frequencies in Patients and Controls
4. Discussion
Limitations of This Study
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Patients N = 125 (%) | Healthy Control N = 155 (%) | * p Value | |
---|---|---|---|
Sex | |||
Male | 72 (57.6) | 76 (43.6) | 0.153 |
Female | 53 (42.4) | 79 (56.4) | |
Age | |||
Range | 21–80 | 28–86 | 0.652 |
Mean ± SD | 59 ± 11.2 | 62.3 ± 13.5 | |
Smoking | |||
Yes | 45 (36) | 61 (39.4) | 0.469 |
No | 71 (56.8) | 80 (51.7) | |
Unknown | 9 (7.2) | 14 (8.9) | |
Alcohol use | |||
Yes | 50 (40) | 56 (36.1) | 0.333 |
No | 65 (52) | 93 (60) | |
Unknown | 10 (8) | 6 (3.9) |
Patients N = 125 (%) | Healthy Controls N = 155 (%) | OR (95% CI) | * p Value | |
---|---|---|---|---|
Genotypes | ||||
CC | 69 (55.2) | 100 (64.5) | 1 | - |
CT | 49 (39.2) | 45 (29) | 1.578 (0.950–2.622) | 0.077 |
TT | 7 (5.6) | 10 (6.5) | 1.014 (0.368–2.795) | 0.978 |
Dominant | ||||
CC | 69 (55.2) | 100 (64.5) | 1 | - |
CT + TT | 56 (44.8) | 55 (35.5) | 1.476 (0.911–2.390) | 0.113 |
Recessive | ||||
CC + CT | 118 (94.4) | 145 (93.5) | 1 | - |
TT | 7 (5.6) | 10 (6.5) | 0.860 (0.318–2.329) | 0.767 |
Allele frequency | ||||
C | 187 (74.8) | 245 (79) | 1 | - |
T | 63 (25.2) | 65 (21) | 1.270 (0.855–1.886) | 0.236 |
Males | Patients N = 72 (%) | Healthy Controls N = 76 (%) | OR (95% CI) | * p Value |
---|---|---|---|---|
Genotypes | ||||
CC | 41 (57) | 55 (72.4) | 1 | - |
CT | 28 (38.9) | 20 (26.3) | 1.878 (0.931–3.790) | 0.077 |
TT | 3 (4.1) | 1 (1.3) | 4.024 (0.404–4.101) | 0.205 |
Females | N = 53 (%) | N = 79 (%) | ||
Genotypes | ||||
CC | 28 (52.8) | 45 (57) | 1 | - |
CT | 21 (39.6) | 25 (31.6) | 1.350 (0.639–2.852) | 0.431 |
TT | 4 (7.6) | 9 (11.4) | 0.714 (0.201–2.540) | 0.604 |
Age ≤ 59 | Patients N = 71 (%) | Controls N = 53 (%) | OR (95% CI) | * p Value |
---|---|---|---|---|
CC | 38 (53.5) | 34 (64.1) | 1 | - |
CT | 31 (43.7) | 13 (24.5) | 2.134 (0.963–4.729) | 0.060 |
TT | 2 (2.8) | 6 (11.4) | 0.298 (0.056–1.578) | 0.139 |
Age > 59 | N = 54 (%) | N = 102 (%) | ||
CC | 31 (57.4) | 66 (64.7) | 1 | - |
CT | 18 (33.3) | 32 (31.4) | 1.198 (0.584–2.456) | 0.622 |
TT | 5 (9.3) | 4 (3.9) | 2.661 (0.668–10.603) | 0.268 |
Genotypes | Smokers N = 45 (%) | Non-Smokers N = 71 (%) | OR (95% CI) | * p Value |
---|---|---|---|---|
CC | 27 (60) | 38 (53.6) | 1 | - |
CT | 16 (35.6) | 28 (39.5) | 0.762 (0.345–1.681) | 0.500 |
TT | 2 (4.4) | 5 (6.9) | 0.533 (0.096–2.961) | 0.470 |
Alcohol Drinkers N = 50 (%) | Non-Drinkers N = 65 (%) | |||
CC | 30 (66.7) | 34 (20) | 1 | - |
CT | 20 (44) | 24 (50.8) | 0.944 (0.437–2.040) | 0.884 |
TT | 0 | 7 (29.2) | - | - |
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Aslanov, H.; Bayramov, B.; Reissfelder, C.; Abdullayeva, S.; Mammadova, Z.; Aliyev, F.; Keese, M.; Hajibabazade, J.; Yagublu, V. MTHFR Gene C677T Polymorphism (rs1801133) and Susceptibility to Colorectal Polyps in an Azerbaijani Population. J. Clin. Med. 2024, 13, 219. https://doi.org/10.3390/jcm13010219
Aslanov H, Bayramov B, Reissfelder C, Abdullayeva S, Mammadova Z, Aliyev F, Keese M, Hajibabazade J, Yagublu V. MTHFR Gene C677T Polymorphism (rs1801133) and Susceptibility to Colorectal Polyps in an Azerbaijani Population. Journal of Clinical Medicine. 2024; 13(1):219. https://doi.org/10.3390/jcm13010219
Chicago/Turabian StyleAslanov, Hazi, Bayram Bayramov, Christoph Reissfelder, Shams Abdullayeva, Zeynab Mammadova, Fikrat Aliyev, Michael Keese, Javahir Hajibabazade, and Vugar Yagublu. 2024. "MTHFR Gene C677T Polymorphism (rs1801133) and Susceptibility to Colorectal Polyps in an Azerbaijani Population" Journal of Clinical Medicine 13, no. 1: 219. https://doi.org/10.3390/jcm13010219
APA StyleAslanov, H., Bayramov, B., Reissfelder, C., Abdullayeva, S., Mammadova, Z., Aliyev, F., Keese, M., Hajibabazade, J., & Yagublu, V. (2024). MTHFR Gene C677T Polymorphism (rs1801133) and Susceptibility to Colorectal Polyps in an Azerbaijani Population. Journal of Clinical Medicine, 13(1), 219. https://doi.org/10.3390/jcm13010219