Persistence Pays Off: Live Birth after Uterus Transplant, Overcoming Recurrent Pregnancy Loss with Cerclage Placement

Johannesson, Liza; Anderson, Sophie; Putman, J. Michael; Gunby, Robert T.; Zhang, Lilly; Testa, Giuliano; Gregg, Anthony R.

doi:10.3390/jcm12206463

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Persistence Pays Off: Live Birth after Uterus Transplant, Overcoming Recurrent Pregnancy Loss with Cerclage Placement

by

Liza Johannesson

^1,2,*

,

Sophie Anderson

³,

J. Michael Putman

⁴,

Robert T. Gunby

²,

Lilly Zhang

⁴,

Giuliano Testa

¹ and

Anthony R. Gregg

⁵

¹

Baylor Annette C. and Harold C. Simmons Transplant Institute, Baylor University Medical Center, Dallas, TX 75246, USA

²

Department of Obstetrics and Gynecology, Baylor University Medical Center, Dallas, TX 75246, USA

³

Fordham University, New York, NY 10458, USA

⁴

Fertility Center of Dallas, Baylor University Medical Center, Dallas, TX 75246, USA

⁵

Department of Obstetrics and Gynecology, Prisma Health Midlands, Columbia, SC 29201, USA

^*

Author to whom correspondence should be addressed.

J. Clin. Med. 2023, 12(20), 6463; https://doi.org/10.3390/jcm12206463

Submission received: 29 August 2023 / Revised: 2 October 2023 / Accepted: 4 October 2023 / Published: 11 October 2023

(This article belongs to the Section Obstetrics & Gynecology)

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Abstract

Recipients of uterus transplantation have unique factors that may increase their risk of cervical insufficiency. This report describes a uterus transplant recipient with cervical insufficiency resulting in two second-trimester miscarriages. After McDonald cerclages (one that failed), she underwent an interval transabdominal cerclage and delivered a healthy term child in her third pregnancy. The longitudinal information of this case provides observations from which we can propose testable hypotheses that address venous outflow and inflammation. This case also suggests that there could be a role for prophylactic cerclage placement at the time of transplantation.

Keywords: cerclage; cervical insufficiency; graft rejection; inflammation; uterus transplantation; venous outflow

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MDPI and ACS Style

Johannesson, L.; Anderson, S.; Putman, J.M.; Gunby, R.T.; Zhang, L.; Testa, G.; Gregg, A.R. Persistence Pays Off: Live Birth after Uterus Transplant, Overcoming Recurrent Pregnancy Loss with Cerclage Placement. J. Clin. Med. 2023, 12, 6463. https://doi.org/10.3390/jcm12206463

AMA Style

Johannesson L, Anderson S, Putman JM, Gunby RT, Zhang L, Testa G, Gregg AR. Persistence Pays Off: Live Birth after Uterus Transplant, Overcoming Recurrent Pregnancy Loss with Cerclage Placement. Journal of Clinical Medicine. 2023; 12(20):6463. https://doi.org/10.3390/jcm12206463

Chicago/Turabian Style

Johannesson, Liza, Sophie Anderson, J. Michael Putman, Robert T. Gunby, Lilly Zhang, Giuliano Testa, and Anthony R. Gregg. 2023. "Persistence Pays Off: Live Birth after Uterus Transplant, Overcoming Recurrent Pregnancy Loss with Cerclage Placement" Journal of Clinical Medicine 12, no. 20: 6463. https://doi.org/10.3390/jcm12206463

APA Style

Johannesson, L., Anderson, S., Putman, J. M., Gunby, R. T., Zhang, L., Testa, G., & Gregg, A. R. (2023). Persistence Pays Off: Live Birth after Uterus Transplant, Overcoming Recurrent Pregnancy Loss with Cerclage Placement. Journal of Clinical Medicine, 12(20), 6463. https://doi.org/10.3390/jcm12206463

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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Persistence Pays Off: Live Birth after Uterus Transplant, Overcoming Recurrent Pregnancy Loss with Cerclage Placement

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