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Volume 12
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10.3390/jcm12010185
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Article
Peer-Review Record

The Risk of BPPV, Meniere’s Disease, and Vestibular Neuronitis in Patients with Gout: A Longitudinal Follow-Up Study Using a National Health Screening Cohort

J. Clin. Med. 2023, 12(1), 185; https://doi.org/10.3390/jcm12010185
by Hyo Geun Choi 1,†, So Young Kim 2,† and Juyong Chung 3,*
Reviewer 1:
Abeir Osman Dabbous
Reviewer 2:
Luigi Califano
J. Clin. Med. 2023, 12(1), 185; https://doi.org/10.3390/jcm12010185
Submission received: 25 November 2022 / Revised: 21 December 2022 / Accepted: 24 December 2022 / Published: 26 December 2022
(This article belongs to the Section Otolaryngology)

Round 1

Reviewer 1 Report

The article is interesting and dealing with important health issues having clinical implications. Moreover, the authors well-addressed the strengths and the limitations of their study.

 

1)Regarding the title of the article:

The authors stated: “Increased Risk of BPPV, Meniere’s Disease, and Vestibular Neuronitis in Patients with Gout: A Longitudinal Follow-Up Study Using a National Health Screening Cohort”.

However, all through the manuscript the authors found Increased Risk of BPPV and Meniere’s Disease with Gout, but not Increased Risk of Vestibular Neuronitis in Patients with Gout. So, it is advisable to modify the title:  The Risk of BPPV, Meniere’s Disease, and Vestibular Neuronitis in Patients with Gout: A Longitudinal Follow-Up Study Using a National Health Screening Cohort.

 

2) Page 12, Line 8:

Repeated word “hyperlipidemia”.

 

3) Figure 2. The authors showed Figure 2.: The Kaplan–Meier failure curve and cumulative incidence function for the occurrence of Meniere’s disease.  What about that for BPPV?

This research addresses the risk of peripheral vestibular diseases with gout. Although an interesting field of research, but does not fill an essential specific gap in the field . Regarding the methodology nd results, I advise teat the statistical methods done to obtain the hazard ratio and the related adjustments and tables , to be revised a a professional statistician prior to its validation for publication due to the complex statistics beyond our experience as audio-vestibular physicians; accordingly any conclusions and assumptions would be hard to judge.   

Author Response

We appreciate the reviewers for their valuable comments. We have revised the manuscript according to their comments and highlighted the changes in the manuscript. Our detailed responses to reviewers’ comments are as follows.

Please see the attachment. 

Author Response File: Author Response.docx

Reviewer 2 Report

Interesting data.Interesting data. I envy you -positively! - for the existence of a similar database. Perhaps it could be emphasized that ethnic factors may be relevant. Above all, I appreciated the idea of potential links through flogistic pathways in Meniere disease.

Author Response

We appreciate the reviewers for their valuable comments. We have revised the manuscript according to their comments and highlighted the changes in the manuscript. Our detailed responses to reviewers’ comments are as follows.

Please see the attachment.

Author Response File: Author Response.docx

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