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Volume 11
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Correction published on 8 December 2022, see J. Clin. Med. 2022, 11(24), 7280.
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Article

Early Postoperative Parathormone and Calcium as Prognostic Factors for Postoperative Hypocalcemia

by
Anna Daskalaki
1,2,*,
Sofia Xenaki
1,
Konstantinos Lasithiotakis
1,
Alexandros Chrysos
1,3,
Marilena Kampa
2,
George Notas
2,4,* and
Emmanuel Chrysos
1
1
Department of General Surgery, University Hospital of Heraklion, 715 00 Heraklion, Greece
2
Laboratory of Experimental Endocrinology, Department of Laboratory Medicine, University of Crete School of Medicine, 715 00 Giofirakia, Greece
3
Department of General, Visceral and Transplantation Surgery, University Clinic RWTH Aachen, 52074 Aachen, Germany
4
Department of Emergency Medicine, University Hospital of Heraklion, 715 00 Heraklion, Greece
*
Authors to whom correspondence should be addressed.
J. Clin. Med. 2022, 11(9), 2389; https://doi.org/10.3390/jcm11092389
Submission received: 17 March 2022 / Revised: 19 April 2022 / Accepted: 21 April 2022 / Published: 24 April 2022 / Corrected: 8 December 2022
(This article belongs to the Section Endocrinology & Metabolism)
Versions Notes

Abstract

Background. Postoperative hypocalcemia is one of the most common complications after total thyroidectomy. Parathormone (PTH) and calcium levels, measured several hours after surgery, have been suggested as valuable markers for detecting patients at risk for post-thyroidectomy hypocalcemia. We aimed to determine if early post-surgery PTH and calcium levels can be used for the early identification of patients at risk for symptomatic hypocalcemia. Methods. PTH and calcium were measured before surgery and at 10 min and 4 h post-thyroidectomy, in 77 patients. Performance characteristics of PTH and calcium levels and their post/pre-surgery ratios were calculated. Results. Four-hour calcium was a sensitive (93.75%) but not specific (67.61%) indicator of patients at risk for symptomatic hypocalcemia. The 4-h/pre-surgery PTH ratio was the most accurate (90.81%) and the most specific (94.37%) test to identify patients at risk. Serum calcium at 4-h, 4-h/pre-surgery PTH ratio, and PTH at 10 min post-surgery had the higher diagnostic odds ratios (50.86, 32.85, and 29.04, respectively). The 4-h/pre-surgery PTH ratio also had the highest (0.694) Youden’s J statistic. Conclusions. Low serum calcium levels 4 h after thyroidectomy and the 4-h/pre-surgery PTH ratio could be valuable additions to everyday clinical practice in post-thyroidectomy patients.
Keywords: hypocalcemia; thyroidectomy; post-surgery; parathormone; calcium hypocalcemia; thyroidectomy; post-surgery; parathormone; calcium

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MDPI and ACS Style

Daskalaki, A.; Xenaki, S.; Lasithiotakis, K.; Chrysos, A.; Kampa, M.; Notas, G.; Chrysos, E. Early Postoperative Parathormone and Calcium as Prognostic Factors for Postoperative Hypocalcemia. J. Clin. Med. 2022, 11, 2389. https://doi.org/10.3390/jcm11092389

AMA Style

Daskalaki A, Xenaki S, Lasithiotakis K, Chrysos A, Kampa M, Notas G, Chrysos E. Early Postoperative Parathormone and Calcium as Prognostic Factors for Postoperative Hypocalcemia. Journal of Clinical Medicine. 2022; 11(9):2389. https://doi.org/10.3390/jcm11092389

Chicago/Turabian Style

Daskalaki, Anna, Sofia Xenaki, Konstantinos Lasithiotakis, Alexandros Chrysos, Marilena Kampa, George Notas, and Emmanuel Chrysos. 2022. "Early Postoperative Parathormone and Calcium as Prognostic Factors for Postoperative Hypocalcemia" Journal of Clinical Medicine 11, no. 9: 2389. https://doi.org/10.3390/jcm11092389

APA Style

Daskalaki, A., Xenaki, S., Lasithiotakis, K., Chrysos, A., Kampa, M., Notas, G., & Chrysos, E. (2022). Early Postoperative Parathormone and Calcium as Prognostic Factors for Postoperative Hypocalcemia. Journal of Clinical Medicine, 11(9), 2389. https://doi.org/10.3390/jcm11092389

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