The Relative Preservation of the Central Retinal Layers in Leber Hereditary Optic Neuropathy
Abstract
:1. Introduction
2. Materials and Methods
2.1. Patients
2.2. Genetic Analysis
2.3. Ophthalmologic Examination and Workup
2.3.1. Electrophysiology
2.3.2. Optical Coherence Tomography and Retinal Segmentation Study
2.3.3. Peripapillary RNFL Thickness Study
2.4. Statistical Analysis
3. Results
3.1. Patient Demographic Data
3.2. Electrophysiology
3.3. Segmentation Analysis
3.3.1. Comparison of Retinal Layers of LHON and nonLHON Group against Healthy Controls
3.3.2. Longitudinal Analysis
3.3.3. Comparison of Retinal Layers’ Thicknesses in ETDRS Rings between LHON and nonLHON Group
3.3.4. Retinal Layer Thickness Ratios between Middle and Outer ETDRS Rings, and Central Circle
3.3.5. Dominant Optic Atrophy Patients
3.4. Peripapillary RNFL (pRNFL) Analysis
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Control vs. LHON (Corrected p-Value) | Control vs. nonLHON (Corrected p-Value) | |||||
---|---|---|---|---|---|---|
ETDRS Ring | ETDRS Ring | |||||
Retinal Layer | Center | Middle | Outer | Center | Middle | Outer |
Retina | 0.101 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 |
GCC | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 |
INL | 0.234 | 1 | 0.275 | 1 | 1 | 1 |
OPL | 1 | 1 | 0.245 | 0.454 | 0.846 | 0.257 |
ONL | 1 | 0.5 | 1 | 1 | 1 | 1 |
Center | Middle | Outer | |||||||
---|---|---|---|---|---|---|---|---|---|
Retinal Layer | c2 | p | Corrected p-Value | c2 | p | Corrected p-Value | c2 | p | Corrected p-Value |
GCC | 11.92 | 0.001 | 0.016 | 5.95 | 0.015 | 0.360 | 4.34 | 0.037 | 0.820 |
INL | 7.3 | 0.007 | 0.200 | 0.45 | 0.503 | 1 | 1.82 | 0.177 | 1 |
OPL | 1.4 | 0.237 | 1 | 0.86 | 0.354 | 1 | 1.12 | 0.289 | 1 |
ONL | 0 | 0.988 | 1 | 1.64 | 0.201 | 1 | 0.1 | 0.754 | 1 |
Outcome | χ2 (1) | df | p | Corrected p Value |
---|---|---|---|---|
RNFL thickness general (G) trend | 1.09 | 1 | 0.297 | 1 |
RNFL thickness inferior nasal trend | 0.53 | 1 | 0.468 | 1 |
RNFL thickness inferior temporal trend | 1.29 | 1 | 0.257 | 1 |
RNFL thickness nasal trend | 1.43 | 1 | 0.232 | 1 |
RNFL thickness superior nasal trend | 0.16 | 1 | 0.687 | 1 |
RNFL thickness superior temporal trend | 10.57 | 1 | 0.001 | 0.008 |
RNFL thickness temporal trend | 4.03 | 1 | 0.045 | 0.268 |
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Petrovic Pajic, S.; Lapajne, L.; Vratanar, B.; Fakin, A.; Jarc-Vidmar, M.; Sustar Habjan, M.; Volk, M.; Maver, A.; Peterlin, B.; Hawlina, M. The Relative Preservation of the Central Retinal Layers in Leber Hereditary Optic Neuropathy. J. Clin. Med. 2022, 11, 6045. https://doi.org/10.3390/jcm11206045
Petrovic Pajic S, Lapajne L, Vratanar B, Fakin A, Jarc-Vidmar M, Sustar Habjan M, Volk M, Maver A, Peterlin B, Hawlina M. The Relative Preservation of the Central Retinal Layers in Leber Hereditary Optic Neuropathy. Journal of Clinical Medicine. 2022; 11(20):6045. https://doi.org/10.3390/jcm11206045
Chicago/Turabian StylePetrovic Pajic, Sanja, Luka Lapajne, Bor Vratanar, Ana Fakin, Martina Jarc-Vidmar, Maja Sustar Habjan, Marija Volk, Ales Maver, Borut Peterlin, and Marko Hawlina. 2022. "The Relative Preservation of the Central Retinal Layers in Leber Hereditary Optic Neuropathy" Journal of Clinical Medicine 11, no. 20: 6045. https://doi.org/10.3390/jcm11206045
APA StylePetrovic Pajic, S., Lapajne, L., Vratanar, B., Fakin, A., Jarc-Vidmar, M., Sustar Habjan, M., Volk, M., Maver, A., Peterlin, B., & Hawlina, M. (2022). The Relative Preservation of the Central Retinal Layers in Leber Hereditary Optic Neuropathy. Journal of Clinical Medicine, 11(20), 6045. https://doi.org/10.3390/jcm11206045