Next Article in Journal
Diagnostic, Therapy and Complications in Acute Appendicitis of 19,749 Cases Based on Routine Data: A Retrospective Multicenter Observational Study
Previous Article in Journal
Correction: Ramírez-Morros et al. Sex Differences in Cardiovascular Prevention in Type 2: Diabetes in a Real-World Practice Database. J. Clin. Med. 2022, 11, 2196
 
 
Article

Association between the Use of Antibiotics and the Development of Acute Renal Injury in Patients Hospitalized for COVID-19 in a Hospital in the Peruvian Amazon

1
Facultad de Medicina Humana, Universidad San Martín de Porres, Chiclayo 15011, Peru
2
Emerge, Unidad de Investigación en Enfermedades Emergentes y Cambio Climático, Facultad de Salud Pública y Administración, Universidad Peruana Cayetano Heredia, Lima 15102, Peru
3
Facultad de Medicina Humana, Universidad Nacional de Ucayali, Pucallpa 25004, Peru
4
Vicerrectorado de Investigación, Universidad Norbert Wiener, Lima 15046, Peru
5
Grupo de Investigación Biomedicina, Faculty of Medicine, Fundación Universitaria Autónoma de las Américas, Pereira 660003, Risaralda, Colombia
6
Institución Universitaria Visión de las Américas, Pereira 660003, Risaralda, Colombia
7
Master of Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima 15067, Peru
*
Author to whom correspondence should be addressed.
Academic Editors: Christian Wunder and Lee Ann MacMillan-Crow
J. Clin. Med. 2022, 11(15), 4493; https://doi.org/10.3390/jcm11154493
Received: 16 May 2022 / Revised: 21 July 2022 / Accepted: 26 July 2022 / Published: 2 August 2022
(This article belongs to the Section Infectious Diseases)
Introduction: A significant antibiotic prescribing pattern associated with the COVID-19 pandemic has been described. Multiple protocols included empirical antimicrobials, leading to a substantial increase in antimicrobial consumption in medical care. A higher mortality rate is described among patients diagnosed with COVID-19 who received antibiotics. Objectives: To determine the association between the use of antibiotics and the development of acute renal injury in patients infected with SARS-CoV-2 in patients treated at the Hospital II EsSalud de Ucayali, 2021. Methods: A cross-sectional-analytical study was conducted, evaluating the medical records of patients admitted to the intensive care unit between July 2020 and July 2021. For the statistical analysis, measures of central tendency and dispersion, statistical hypothesis contrast tests were used in relation to acute kidney injury (AKI), antibiotic use and associated factors, derived from linear regression models. Results: The factors that were positively associated with the development of AKI were sepsis (aPR: 2.86; 95% CI: 1.26–6.43), shock (aPR:2.49; 95% CI: 1.28–4.86), mechanical ventilation (aPR:9.11; 95% CI: 1.23–67.57), and use of vancomycin (aPR: 3.15; 95% CI: 1.19–8.27). Conclusions: In the Peruvian Amazon, there is a high consumption and inadequate prescription of antibiotics. The drugs most commonly used for the treatment of COVID-19 were: aminoglycosides, vancomycin, ivermectin, azithromycin, tocilizumab, and corticosteroids. The development of AKI among hospitalized patients was found to be related to vancomycin administration. In addition, an association was found with the use of mechanical ventilation, a high body mass index, and the presence of complications such as sepsis or shock. Therefore, inappropriate antibiotic use for COVID-19 has been associated with multiple negative outcomes and consequences. View Full-Text
Keywords: COVID-19; acute kidney injury; intensive care units; antibacterials COVID-19; acute kidney injury; intensive care units; antibacterials
Show Figures

Figure 1

MDPI and ACS Style

Romaní, L.; León-Figueroa, D.A.; Rafael-Navarro, D.; Barboza, J.J.; Rodriguez-Morales, A.J. Association between the Use of Antibiotics and the Development of Acute Renal Injury in Patients Hospitalized for COVID-19 in a Hospital in the Peruvian Amazon. J. Clin. Med. 2022, 11, 4493. https://doi.org/10.3390/jcm11154493

AMA Style

Romaní L, León-Figueroa DA, Rafael-Navarro D, Barboza JJ, Rodriguez-Morales AJ. Association between the Use of Antibiotics and the Development of Acute Renal Injury in Patients Hospitalized for COVID-19 in a Hospital in the Peruvian Amazon. Journal of Clinical Medicine. 2022; 11(15):4493. https://doi.org/10.3390/jcm11154493

Chicago/Turabian Style

Romaní, Luccio, Darwin A. León-Figueroa, David Rafael-Navarro, Joshuan J. Barboza, and Alfonso J. Rodriguez-Morales. 2022. "Association between the Use of Antibiotics and the Development of Acute Renal Injury in Patients Hospitalized for COVID-19 in a Hospital in the Peruvian Amazon" Journal of Clinical Medicine 11, no. 15: 4493. https://doi.org/10.3390/jcm11154493

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop