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Remdesivir in Very Old Patients (≥80 Years) Hospitalized with COVID-19: Real World Data from the SEMI-COVID-19 Registry

Department of Clinical Medicine, Miguel Hernandez University of Elche, Ctra N332 s/n, 03550 Alicante, Spain
Department of Internal Medicine, Instituto de Investigacion Biomedica de Málaga (IBIMA), Regional University Hospital of Málaga, 29010 Málaga, Spain
Department of Medicine, University of Málaga, 29010 Málaga, Spain
Internal Medicine Department, Bellvitge University Hospital, L’Hospitalet de Llobregat, 08907 Barcelona, Spain
Internal Medicine Department, Costa del Sol Hospital, 29603 Marbella, Spain
Internal Medicine Department, Doce de Octubre University Hospital, 28041 Madrid, Spain
Internal Medicine Department, Cabueñes University Hospital, 33394 Gijón, Spain
Internal Medicine Department, Gregorio Marañón General University Hospital, 28007 Madrid, Spain
Internal Medicine Department, Santa Marina Hospital, 48004 Bilbo, Spain
Internal Medicine Department, HLA Moncloa University Hospital, 28008 Madrid, Spain
Internal Medicine Department, Zamora Hospital Complex, 49022 Zamora, Spain
Internal Medicine Department, Nuestra Señora Candelaria University Hospital, 38010 Santa Cruz de Tenerife, Spain
Internal Medicine Department, Leon University Hospital Complex, 24071 León, Spain
Internal Medicine Department, Torrecárdenas University Hospital, 04009 Almería, Spain
Internal Medicine Department, Insular University Hospital Complex, 35016 Las Palmas de Gran Canaria, Spain
Internal Medicine Department, Central Asturias, University Hospital, 33011 Oviedo, Spain
Internal Medicine Department, Francesc de Borja Hospital, 46702 Gandia, Spain
Internal Medicine Department, Quironsalud A Coruña Hospital, 15009 A Coruña, Spain
CIBER Fisiopatologia de la Obesidad y la Nutricion, Carlos III Health Institute, 28029 Madrid, Spain
Author to whom correspondence should be addressed.
A complete list of the SEMI-COVID-19 Network members is provided in the Appendix A.
Academic Editor: Valeria Ghisetti
J. Clin. Med. 2022, 11(13), 3769;
Received: 13 May 2022 / Revised: 24 June 2022 / Accepted: 25 June 2022 / Published: 29 June 2022
(This article belongs to the Special Issue COVID-19: Special Populations and Risk Factors)
(1) Background: Large cohort studies of patients with COVID-19 treated with remdesivir have reported improved clinical outcomes, but data on older patients are scarce. Objective: This work aims to assess the potential benefit of remdesivir in unvaccinated very old patients hospitalized with COVID-19; (2) Methods: This is a retrospective analysis of patients ≥ 80 years hospitalized in Spain between 15 July and 31 December 2020 (SEMI-COVID-19 Registry). Differences in 30-day all-cause mortality were adjusted using a multivariable regression analysis. (3) Results: Of the 4331 patients admitted, 1312 (30.3%) were ≥80 years. Very old patients treated with remdesivir (n: 140, 10.7%) had a lower mortality rate than those not treated with remdesivir (OR (95% CI): 0.45 (0.29–0.69)). After multivariable adjustment by age, sex, and variables associated with lower mortality (place of COVID-19 acquisition; degree of dependence; comorbidities; dementia; duration of symptoms; admission qSOFA; chest X-ray; D-dimer; and treatment with corticosteroids, tocilizumab, beta-lactams, macrolides, and high-flow nasal canula oxygen), the use of remdesivir remained associated with a lower 30-day all-cause mortality rate (adjusted OR (95% CI): 0.40 (0.22–0.61) (p < 0.001)). (4) Conclusions: Remdesivir may reduce mortality in very old patients hospitalized with COVID-19. View Full-Text
Keywords: COVID-19; SARS-CoV-2; age ≥ 80; remdesivir; mortality; Spain COVID-19; SARS-CoV-2; age ≥ 80; remdesivir; mortality; Spain
MDPI and ACS Style

Ramos-Rincon, J.-M.; López-Carmona, M.-D.; Cobos-Palacios, L.; López-Sampalo, A.; Rubio-Rivas, M.; Martín-Escalante, M.-D.; de-Cossio-Tejido, S.; Taboada-Martínez, M.-L.; Muiño-Miguez, A.; Areses-Manrique, M.; Martinez-Cilleros, C.; Tuñón-de-Almeida, C.; Abella-Vázquez, L.; Martínez-Gonzalez, A.-L.; Díez-García, L.-F.; Ripper, C.-J.; Asensi, V.; Martinez-Pascual, A.; Guisado-Vasco, P.; Lumbreras-Bermejo, C.; Gómez-Huelgas, R.; on behalf of the SEMI-COVID-19 Network. Remdesivir in Very Old Patients (≥80 Years) Hospitalized with COVID-19: Real World Data from the SEMI-COVID-19 Registry. J. Clin. Med. 2022, 11, 3769.

AMA Style

Ramos-Rincon J-M, López-Carmona M-D, Cobos-Palacios L, López-Sampalo A, Rubio-Rivas M, Martín-Escalante M-D, de-Cossio-Tejido S, Taboada-Martínez M-L, Muiño-Miguez A, Areses-Manrique M, Martinez-Cilleros C, Tuñón-de-Almeida C, Abella-Vázquez L, Martínez-Gonzalez A-L, Díez-García L-F, Ripper C-J, Asensi V, Martinez-Pascual A, Guisado-Vasco P, Lumbreras-Bermejo C, Gómez-Huelgas R, on behalf of the SEMI-COVID-19 Network. Remdesivir in Very Old Patients (≥80 Years) Hospitalized with COVID-19: Real World Data from the SEMI-COVID-19 Registry. Journal of Clinical Medicine. 2022; 11(13):3769.

Chicago/Turabian Style

Ramos-Rincon, Jose-Manuel, María-Dolores López-Carmona, Lidia Cobos-Palacios, Almudena López-Sampalo, Manuel Rubio-Rivas, María-Dolores Martín-Escalante, Santiago de-Cossio-Tejido, María-Luisa Taboada-Martínez, Antonio Muiño-Miguez, Maria Areses-Manrique, Carmen Martinez-Cilleros, Carlota Tuñón-de-Almeida, Lucy Abella-Vázquez, Angel-Luís Martínez-Gonzalez, Luis-Felipe Díez-García, Carlos-Jorge Ripper, Victor Asensi, Angeles Martinez-Pascual, Pablo Guisado-Vasco, Carlos Lumbreras-Bermejo, Ricardo Gómez-Huelgas, and on behalf of the SEMI-COVID-19 Network. 2022. "Remdesivir in Very Old Patients (≥80 Years) Hospitalized with COVID-19: Real World Data from the SEMI-COVID-19 Registry" Journal of Clinical Medicine 11, no. 13: 3769.

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