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Remdesivir in Very Old Patients (≥80 Years) Hospitalized with COVID-19: Real World Data from the SEMI-COVID-19 Registry

1
Department of Clinical Medicine, Miguel Hernandez University of Elche, Ctra N332 s/n, 03550 Alicante, Spain
2
Department of Internal Medicine, Instituto de Investigacion Biomedica de Málaga (IBIMA), Regional University Hospital of Málaga, 29010 Málaga, Spain
3
Department of Medicine, University of Málaga, 29010 Málaga, Spain
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Internal Medicine Department, Bellvitge University Hospital, L’Hospitalet de Llobregat, 08907 Barcelona, Spain
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Internal Medicine Department, Costa del Sol Hospital, 29603 Marbella, Spain
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Internal Medicine Department, Doce de Octubre University Hospital, 28041 Madrid, Spain
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Internal Medicine Department, Cabueñes University Hospital, 33394 Gijón, Spain
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Internal Medicine Department, Gregorio Marañón General University Hospital, 28007 Madrid, Spain
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Internal Medicine Department, Santa Marina Hospital, 48004 Bilbo, Spain
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Internal Medicine Department, HLA Moncloa University Hospital, 28008 Madrid, Spain
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Internal Medicine Department, Zamora Hospital Complex, 49022 Zamora, Spain
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Internal Medicine Department, Nuestra Señora Candelaria University Hospital, 38010 Santa Cruz de Tenerife, Spain
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Internal Medicine Department, Leon University Hospital Complex, 24071 León, Spain
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Internal Medicine Department, Torrecárdenas University Hospital, 04009 Almería, Spain
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Internal Medicine Department, Insular University Hospital Complex, 35016 Las Palmas de Gran Canaria, Spain
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Internal Medicine Department, Central Asturias, University Hospital, 33011 Oviedo, Spain
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Internal Medicine Department, Francesc de Borja Hospital, 46702 Gandia, Spain
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Internal Medicine Department, Quironsalud A Coruña Hospital, 15009 A Coruña, Spain
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CIBER Fisiopatologia de la Obesidad y la Nutricion, Carlos III Health Institute, 28029 Madrid, Spain
*
Author to whom correspondence should be addressed.
A complete list of the SEMI-COVID-19 Network members is provided in the Appendix A.
Academic Editor: Valeria Ghisetti
J. Clin. Med. 2022, 11(13), 3769; https://doi.org/10.3390/jcm11133769
Received: 13 May 2022 / Revised: 24 June 2022 / Accepted: 25 June 2022 / Published: 29 June 2022
(This article belongs to the Special Issue COVID-19: Special Populations and Risk Factors)
(1) Background: Large cohort studies of patients with COVID-19 treated with remdesivir have reported improved clinical outcomes, but data on older patients are scarce. Objective: This work aims to assess the potential benefit of remdesivir in unvaccinated very old patients hospitalized with COVID-19; (2) Methods: This is a retrospective analysis of patients ≥ 80 years hospitalized in Spain between 15 July and 31 December 2020 (SEMI-COVID-19 Registry). Differences in 30-day all-cause mortality were adjusted using a multivariable regression analysis. (3) Results: Of the 4331 patients admitted, 1312 (30.3%) were ≥80 years. Very old patients treated with remdesivir (n: 140, 10.7%) had a lower mortality rate than those not treated with remdesivir (OR (95% CI): 0.45 (0.29–0.69)). After multivariable adjustment by age, sex, and variables associated with lower mortality (place of COVID-19 acquisition; degree of dependence; comorbidities; dementia; duration of symptoms; admission qSOFA; chest X-ray; D-dimer; and treatment with corticosteroids, tocilizumab, beta-lactams, macrolides, and high-flow nasal canula oxygen), the use of remdesivir remained associated with a lower 30-day all-cause mortality rate (adjusted OR (95% CI): 0.40 (0.22–0.61) (p < 0.001)). (4) Conclusions: Remdesivir may reduce mortality in very old patients hospitalized with COVID-19. View Full-Text
Keywords: COVID-19; SARS-CoV-2; age ≥ 80; remdesivir; mortality; Spain COVID-19; SARS-CoV-2; age ≥ 80; remdesivir; mortality; Spain
MDPI and ACS Style

Ramos-Rincon, J.-M.; López-Carmona, M.-D.; Cobos-Palacios, L.; López-Sampalo, A.; Rubio-Rivas, M.; Martín-Escalante, M.-D.; de-Cossio-Tejido, S.; Taboada-Martínez, M.-L.; Muiño-Miguez, A.; Areses-Manrique, M.; Martinez-Cilleros, C.; Tuñón-de-Almeida, C.; Abella-Vázquez, L.; Martínez-Gonzalez, A.-L.; Díez-García, L.-F.; Ripper, C.-J.; Asensi, V.; Martinez-Pascual, A.; Guisado-Vasco, P.; Lumbreras-Bermejo, C.; Gómez-Huelgas, R.; on behalf of the SEMI-COVID-19 Network. Remdesivir in Very Old Patients (≥80 Years) Hospitalized with COVID-19: Real World Data from the SEMI-COVID-19 Registry. J. Clin. Med. 2022, 11, 3769. https://doi.org/10.3390/jcm11133769

AMA Style

Ramos-Rincon J-M, López-Carmona M-D, Cobos-Palacios L, López-Sampalo A, Rubio-Rivas M, Martín-Escalante M-D, de-Cossio-Tejido S, Taboada-Martínez M-L, Muiño-Miguez A, Areses-Manrique M, Martinez-Cilleros C, Tuñón-de-Almeida C, Abella-Vázquez L, Martínez-Gonzalez A-L, Díez-García L-F, Ripper C-J, Asensi V, Martinez-Pascual A, Guisado-Vasco P, Lumbreras-Bermejo C, Gómez-Huelgas R, on behalf of the SEMI-COVID-19 Network. Remdesivir in Very Old Patients (≥80 Years) Hospitalized with COVID-19: Real World Data from the SEMI-COVID-19 Registry. Journal of Clinical Medicine. 2022; 11(13):3769. https://doi.org/10.3390/jcm11133769

Chicago/Turabian Style

Ramos-Rincon, Jose-Manuel, María-Dolores López-Carmona, Lidia Cobos-Palacios, Almudena López-Sampalo, Manuel Rubio-Rivas, María-Dolores Martín-Escalante, Santiago de-Cossio-Tejido, María-Luisa Taboada-Martínez, Antonio Muiño-Miguez, Maria Areses-Manrique, Carmen Martinez-Cilleros, Carlota Tuñón-de-Almeida, Lucy Abella-Vázquez, Angel-Luís Martínez-Gonzalez, Luis-Felipe Díez-García, Carlos-Jorge Ripper, Victor Asensi, Angeles Martinez-Pascual, Pablo Guisado-Vasco, Carlos Lumbreras-Bermejo, Ricardo Gómez-Huelgas, and on behalf of the SEMI-COVID-19 Network. 2022. "Remdesivir in Very Old Patients (≥80 Years) Hospitalized with COVID-19: Real World Data from the SEMI-COVID-19 Registry" Journal of Clinical Medicine 11, no. 13: 3769. https://doi.org/10.3390/jcm11133769

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