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Abnormal Liver Function Test in Patients Infected with Coronavirus (SARS-CoV-2): A Retrospective Single-Center Study from Spain

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Department of Immunology, Ophthalmology & ENT, Complutense University School of Medicine, 28040 Madrid, Spain
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Department of Genetics, Physiology and Microbiology, Faculty of Biology, Complutense University, 28040 Madrid, Spain
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iBroker Global Markets, SV, SA, 28033 Madrid, Spain
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Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City 14080, Mexico
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12 de Octubre Health Research Institute (imas12), 28041 Madrid, Spain
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Hepatology Program, CIMA, University of Navarra, 31009 Pamplona, Spain
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Instituto de Investigaciones Sanitarias de Navarra IdiSNA, 31008 Pamplona, Spain
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CIBERehd, Instituto de Salud Carlos III, 28220 Madrid, Spain
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Department of Internal Medicine III, University Hospital RWTH Aachen, 52074 Aachen, Germany
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Health Research Institute Gregorio Marañón (IiSGM), 28007 Madrid, Spain
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Barcelona Hepatic Haemodynamic Laboratory, Liver Unit, Institute of Digestive and Metabolic Diseases, August Pi I Sunyer Institute of Biomedical Research, Hospital Clinic, 08036 Barcelona, Spain
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Inselspital, Bern University, 3010 Bern, Switzerland
*
Authors to whom correspondence should be addressed.
Contributed equally as first authors.
Contributed equally as senior authors.
J. Clin. Med. 2021, 10(5), 1039; https://doi.org/10.3390/jcm10051039
Received: 6 January 2021 / Revised: 23 February 2021 / Accepted: 23 February 2021 / Published: 3 March 2021
(This article belongs to the Section Infectious Diseases)
The outbreak of the novel coronavirus SARS-CoV-2 epidemic has rapidly spread and still poses a serious threat to healthcare systems worldwide. In the present study, electronic medical records containing clinical indicators related to liver injury in 799 COVID-19-confirmed patients admitted to a hospital in Madrid (Spain) were extracted and analyzed. Correlation between liver injury and disease outcome was also evaluated. Serum levels of Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), Gamma-glutamyltransferase (GGT), Alkaline phosphatase (ALP), Lactate dehydrogenase (LDH) and AST/ALT ratio were elevated above the Upper Limit of Normal (ULN) in 25.73%, 49.17%, 34.62%, 24.21%, 55.84% and 75% of patients, respectively. Interestingly, significant positive correlation between LDH levels and the AST/ALT ratio with disease outcome was found. Our data showed that SARS-CoV-2 virus infection leads to mild, but significant changes in serum markers of liver injury. The upregulated LDH levels as well as AST/ALT ratios upon admission may be used as additional diagnostic characteristic for COVID-19 patients. View Full-Text
Keywords: SARS-CoV-2; liver injury; pandemic; AST/ALT ratio; ferritin SARS-CoV-2; liver injury; pandemic; AST/ALT ratio; ferritin
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MDPI and ACS Style

Benedé-Ubieto, R.; Estévez-Vázquez, O.; Flores-Perojo, V.; Macías-Rodríguez, R.U.; Ruiz-Margáin, A.; Martínez-Naves, E.; Regueiro, J.R.; Ávila, M.A.; Trautwein, C.; Bañares, R.; Bosch, J.; Cubero, F.J.; Nevzorova, Y.A. Abnormal Liver Function Test in Patients Infected with Coronavirus (SARS-CoV-2): A Retrospective Single-Center Study from Spain. J. Clin. Med. 2021, 10, 1039. https://doi.org/10.3390/jcm10051039

AMA Style

Benedé-Ubieto R, Estévez-Vázquez O, Flores-Perojo V, Macías-Rodríguez RU, Ruiz-Margáin A, Martínez-Naves E, Regueiro JR, Ávila MA, Trautwein C, Bañares R, Bosch J, Cubero FJ, Nevzorova YA. Abnormal Liver Function Test in Patients Infected with Coronavirus (SARS-CoV-2): A Retrospective Single-Center Study from Spain. Journal of Clinical Medicine. 2021; 10(5):1039. https://doi.org/10.3390/jcm10051039

Chicago/Turabian Style

Benedé-Ubieto, Raquel, Olga Estévez-Vázquez, Vicente Flores-Perojo, Ricardo U. Macías-Rodríguez, Astrid Ruiz-Margáin, Eduardo Martínez-Naves, José R. Regueiro, Matías A. Ávila, Christian Trautwein, Rafael Bañares, Jaume Bosch, Francisco J. Cubero, and Yulia A. Nevzorova. 2021. "Abnormal Liver Function Test in Patients Infected with Coronavirus (SARS-CoV-2): A Retrospective Single-Center Study from Spain" Journal of Clinical Medicine 10, no. 5: 1039. https://doi.org/10.3390/jcm10051039

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