Next Article in Journal
Epidemiological Impact of Myocarditis
Next Article in Special Issue
Adult-Onset Still’s Disease: Clinical Aspects and Therapeutic Approach
Previous Article in Journal
Can Use of Digital Technologies by People with Dementia Improve Self-Management and Social Participation? A Systematic Review of Effect Studies
Previous Article in Special Issue
Tumor Necrosis Factor Receptor-Associated Periodic Syndrome (TRAPS) with a New Pathogenic Variant in TNFRSF1A Gene in a Family of the Adult Male with Renal AA Amyloidosis—Diagnostic and Therapeutic Challenge for Clinicians
Article

COVID-19 in Autoinflammatory Diseases with Immunosuppressive Treatment

1
Pediatric Rheumatology and Autoinflammation Reference Center Tuebingen (arcT), University Children’s Hospital Tuebingen, 72076 Tuebingen, Germany
2
Pediatric Pharmacology and Pharmacometrics, University Children‘s Hospital Basel (UKBB), University of Basel, 4056 Basel, Switzerland
3
Department of Internal Medicine II, Immunopathological Laboratory, 72076 Tuebingen, Germany
4
Divison of Clinical Pharmacology, Children’s National Hospital, 111 Michigan Avenue, NW, Washington, DC 20010, USA
*
Author to whom correspondence should be addressed.
The authors contributed equally.
Academic Editor: Eugen Feist; Eugen Feist; Erkan Demirkaya
J. Clin. Med. 2021, 10(4), 605; https://doi.org/10.3390/jcm10040605
Received: 27 November 2020 / Revised: 19 January 2021 / Accepted: 2 February 2021 / Published: 5 February 2021
(This article belongs to the Special Issue Systemic Autoinflammatory Diseases—Clinical Rheumatic Challenges)
COVID-19 disease increases interleukin (IL)-1β release. Anti-IL-1-treatment is effective in IL-1-mediated autoinflammatory diseases (AID). This case series presents COVID-19 in patients with IL-1-mediated and unclassified AID with immunosuppressive therapy (IT). Patient 1 is a 34-year-old woman with an unclassified AID and methotrexate. Patients 2 and 3 (14-year-old girl and 12-year-old boy, respectively) have a Cryopyrin-Associated Periodic Syndrome (NLRP3 p.Q703K heterozygous, CAPS) treated with canakinumab 150 mg/month since three and five years, respectively. Patient 4 is a 15-year-old girl who has had familial Mediterranean fever (MEFV p.M694V homozygous) for 3 years treated with canakinumab 150 mg/month and colchicine. All patients had a mild acute COVID-19 course, particularly the adolescent patients. A few weeks after COVID-19 recovery, both CAPS patients developed increased AID activity, necessitating anti-IL-1-treatment intensification in one patient. At day 100, one out of four patients (25%) showed positive antibody response to SARS-CoV-2. This is one of the first reports providing follow-up data about COVID-19 in AID. The risk for severe acute COVID-19 disease was mild/moderate, but increased AID activity post-COVID-19 was detected. Follow-up data and data combination are needed to expand understanding of COVID-19 and SARS-CoV-2 immunity in AID and the role of IT. View Full-Text
Keywords: Interleukin-1; autoinflammatory diseases; CAPS; FMF; coronavirus; SARS-CoV-2 antibody response Interleukin-1; autoinflammatory diseases; CAPS; FMF; coronavirus; SARS-CoV-2 antibody response
Show Figures

Figure 1

MDPI and ACS Style

Welzel, T.; Samba, S.D.; Klein, R.; van den Anker, J.N.; Kuemmerle-Deschner, J.B. COVID-19 in Autoinflammatory Diseases with Immunosuppressive Treatment. J. Clin. Med. 2021, 10, 605. https://doi.org/10.3390/jcm10040605

AMA Style

Welzel T, Samba SD, Klein R, van den Anker JN, Kuemmerle-Deschner JB. COVID-19 in Autoinflammatory Diseases with Immunosuppressive Treatment. Journal of Clinical Medicine. 2021; 10(4):605. https://doi.org/10.3390/jcm10040605

Chicago/Turabian Style

Welzel, Tatjana, Samuel D. Samba, Reinhild Klein, Johannes N. van den Anker, and Jasmin B. Kuemmerle-Deschner 2021. "COVID-19 in Autoinflammatory Diseases with Immunosuppressive Treatment" Journal of Clinical Medicine 10, no. 4: 605. https://doi.org/10.3390/jcm10040605

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop