Assessment of Lymph Node Involvement with PET-CT in Advanced Epithelial Ovarian Cancer. A FRANCOGYN Group Study

Tardieu, Antoine; Ouldamer, Lobna; Margueritte, François; Rossard, Lauranne; Lacorre, Aymeline; Bourdel, Nicolas; Lades, Guillaume; Sallée, Camille; Monteil, Jacques; Gauthier, Tristan

doi:10.3390/jcm10040602

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Assessment of Lymph Node Involvement with PET-CT in Advanced Epithelial Ovarian Cancer. A FRANCOGYN Group Study

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Department of Gynecology and Obstetrics, CHU Limoges, 8 Avenue Dominique Larrey, CEDEX, 87042 Limoges, France

Department of Gynecology and Obstetrics, Tours University Hospital, CEDEX, 37000 Tours, France

Poissy-Saint-Germain-en-Laye Hospital Center, Department of Gynecology and Obstetrics, CEDEX, 78100 Saint-Germain-en-Laye, France

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Department of Gynecology and Obstetrics, Clermont Ferrand University Hospital, CEDEX, 63000 Clermont Ferrand, France

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Nuclear Medicine Department, Limoges University Hospital, 87042 Limoges, France

Author to whom correspondence should be addressed.

Academic Editor: Vincent Lavoue

J. Clin. Med. 2021, 10(4), 602; https://doi.org/10.3390/jcm10040602

Received: 16 December 2020 / Revised: 29 January 2021 / Accepted: 3 February 2021 / Published: 5 February 2021

(This article belongs to the Special Issue Ovarian Cancer: Latest Advances and Prospects)

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Abstract

The objective of our study is to evaluate the diagnostic performance of positron emission tomography/computed tomography (PET-CT) for the assessment of lymph node involvement in advanced epithelial ovarian, fallopian tubal or peritoneal cancer (EOC). This was a retrospective, bicentric study. We included all patients over 18 years of age with a histological diagnosis of advanced EOC who had undergone PET-CT at the time of diagnosis or prior to cytoreduction surgery with pelvic or para-aortic lymphadenectomy. We included 145 patients with primary advanced EOC. The performance of PET-CT was calculated from the data of 63 patients. The sensitivity of PET-CT for preoperative lymph node evaluation was 26.7%, specificity was 90.9%, PPV was 72.7%, and NPV was 57.7%. The accuracy rate was 60.3%, and the false-negative rate was 34.9%. In the case of primary cytoreduction (n = 16), the sensitivity of PET-CT was 50%, specificity was 87.5%, PPV was 80%, and NPV was 63.6%. The accuracy rate was 68.8%, and the false negative rate was 25%. After neoadjuvant chemotherapy (n = 47), the sensitivity of PET-CT was 18.2%, specificity was 92%, PPV was 66.7%, and NPV was 56.1%. The accuracy rate was 57.5%, and the false negative rate was 38.3%. Due to its high specificity, the performance of a preoperative PET-CT scan could contribute to the de-escalation and reduction of lymphadenectomy in the surgical management of advanced EOC in a significant number of patients free of lymph node metastases. View Full-Text

Keywords: advanced epithelial ovarian cancer; positron emission tomography/computed tomography; lymphadenectomy

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Tardieu, A.; Ouldamer, L.; Margueritte, F.; Rossard, L.; Lacorre, A.; Bourdel, N.; Lades, G.; Sallée, C.; Monteil, J.; Gauthier, T. Assessment of Lymph Node Involvement with PET-CT in Advanced Epithelial Ovarian Cancer. A FRANCOGYN Group Study. J. Clin. Med. 2021, 10, 602. https://doi.org/10.3390/jcm10040602

AMA Style

Tardieu A, Ouldamer L, Margueritte F, Rossard L, Lacorre A, Bourdel N, Lades G, Sallée C, Monteil J, Gauthier T. Assessment of Lymph Node Involvement with PET-CT in Advanced Epithelial Ovarian Cancer. A FRANCOGYN Group Study. Journal of Clinical Medicine. 2021; 10(4):602. https://doi.org/10.3390/jcm10040602

Chicago/Turabian Style

Tardieu, Antoine, Lobna Ouldamer, François Margueritte, Lauranne Rossard, Aymeline Lacorre, Nicolas Bourdel, Guillaume Lades, Camille Sallée, Jacques Monteil, and Tristan Gauthier. 2021. "Assessment of Lymph Node Involvement with PET-CT in Advanced Epithelial Ovarian Cancer. A FRANCOGYN Group Study" Journal of Clinical Medicine 10, no. 4: 602. https://doi.org/10.3390/jcm10040602

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Assessment of Lymph Node Involvement with PET-CT in Advanced Epithelial Ovarian Cancer. A FRANCOGYN Group Study

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