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Article

Hemoadsorption during Cardiopulmonary Bypass in Patients with Endocarditis Undergoing Valve Surgery: A Retrospective Single-Center Study

1
Department of Cardiac Surgery, University Hospital Basel, 4031 Basel, Switzerland
2
Department of Intensive Care Medicine, University Hospital Basel, 4031 Basel, Switzerland
3
Department of Clinical Research, University Hospital Basel, 4031 Basel, Switzerland
*
Author to whom correspondence should be addressed.
Academic Editors: Francesco Onorati, Francesco Nicolini and Eduard Quintana
J. Clin. Med. 2021, 10(4), 564; https://doi.org/10.3390/jcm10040564
Received: 21 December 2020 / Revised: 27 January 2021 / Accepted: 29 January 2021 / Published: 3 February 2021
(This article belongs to the Special Issue New Perspectives in Cardiovascular Surgery)
Background: Aim of this study was to evaluate the outcomes of endocarditis patients undergoing valve surgery with the Cytosorb® hemoadsorption (HA) device during cardiopulmonary bypass. Methods: From 2009 until 2019, 241 patients had undergone valve surgery due to endocarditis at the Department of Cardiac Surgery, University Hospital of Basel. We compared patients who received HA during surgery (n = 41) versus patients without HA (n = 200), after applying inverse probability of treatment weighting. Results: In-hospital mortality, major adverse cardiac and cerebrovascular events and postoperative renal failure were similar in both groups. Demand for norepinephrine (88.4 vs. 52.8%; p = 0.001), milrinone (42.2 vs. 17.2%; p = 0.046), red blood cell concentrates (65.2 vs. 30.6%; p = 0.003), and platelets (HA vs. Control: 36.7 vs. 9.8%; p = 0.013) were higher in the HA group. In addition, a higher incidence of reoperation for bleeding (34.0 vs. 7.7 %; p = 0.011), and a prolonged length of in-hospital stay (15.2 (11.8 to 19.6) vs. 9.0 (7.1 to 11.3) days; p = 0.017) were observed in the HA group. Conclusions: No benefits of HA-therapy were observed in patients with infective endocarditis undergoing valve surgery. View Full-Text
Keywords: endocarditis; cardiopulmonary bypass; hemoadsorption; Cytosorb; blood purification; sepsis; cardiac surgery; valve surgery endocarditis; cardiopulmonary bypass; hemoadsorption; Cytosorb; blood purification; sepsis; cardiac surgery; valve surgery
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MDPI and ACS Style

Santer, D.; Miazza, J.; Koechlin, L.; Gahl, B.; Rrahmani, B.; Hollinger, A.; Eckstein, F.S.; Siegemund, M.; Reuthebuch, O.T. Hemoadsorption during Cardiopulmonary Bypass in Patients with Endocarditis Undergoing Valve Surgery: A Retrospective Single-Center Study. J. Clin. Med. 2021, 10, 564. https://doi.org/10.3390/jcm10040564

AMA Style

Santer D, Miazza J, Koechlin L, Gahl B, Rrahmani B, Hollinger A, Eckstein FS, Siegemund M, Reuthebuch OT. Hemoadsorption during Cardiopulmonary Bypass in Patients with Endocarditis Undergoing Valve Surgery: A Retrospective Single-Center Study. Journal of Clinical Medicine. 2021; 10(4):564. https://doi.org/10.3390/jcm10040564

Chicago/Turabian Style

Santer, David, Jules Miazza, Luca Koechlin, Brigitta Gahl, Bejtush Rrahmani, Alexa Hollinger, Friedrich S. Eckstein, Martin Siegemund, and Oliver T. Reuthebuch. 2021. "Hemoadsorption during Cardiopulmonary Bypass in Patients with Endocarditis Undergoing Valve Surgery: A Retrospective Single-Center Study" Journal of Clinical Medicine 10, no. 4: 564. https://doi.org/10.3390/jcm10040564

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